Submitted: 29 Feb 2016
Accepted: 13 Mar 2016
First published online: 15 Mar 2016
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J Cardiovasc Thorac Res. 2016;8(1):34-39.
doi: 10.15171/jcvtr.2016.06
PMID: 27069565
PMCID: PMC4827137
  Abstract View: 568
  PDF Download: 710

Original Article

Statin drugs mitigate cellular inflammatory response after ST elevation myocardial infarction, but do not affect in-hospital mortality

Leili Pourafkari 1,2, Ognjen Visnjevac 2, Samad Ghaffari 1, Nader D. Nader 2 *

1 Cardovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 State University of New York at Buffalo, Buffalo, NY, USA

Abstract

Introduction: The objective was to examine the role of statins in modulating post-STEMI inflammation and related mortality.
Methods:
A total of 404 patients with STEMI were reviewed. Demographics, comorbidities, laboratory values, and outcomes were collected. The patients were grouped as STATIN and NOSTAT based on the use of statin drugs at the time of admission. Ninety-seven patients were receiving statin drugs.
Results: The patients in the STATIN group were more likely to be hypertensive (53.6%), diabetic (37.1%) and to have previous coronary revascularization (9.3%). Following propensity matching of 89 patients in STATIN group to an equal number of patients in NOSTAT controls had lower neutrophil count 7.8 (6.8-8.4) compared to those in the NOSTAT group 9.1 (7.9-10.1). Although there was no difference in-hospital mortality between the two groups, the incidence of pump failure was lower in the STATIN group (5.6% vs. 15.7%; P < 0.01).
Conclusion:
Statin treatment prior to STEMI mitigates the cellular inflammatory response after the myocardial infarction, as evidenced by lower leukocyte and neutrophil cell counts in the STATIN group.
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