Logo-jcvtr
Submitted: 08 Jul 2015
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Cardiovasc Thorac Res. 2015;7(3): 107-112.
doi: 10.15171/jcvtr.2015.23
PMID: 26430498
PMCID: PMC4586596
  Abstract View: 1510
  PDF Download: 851

Original Article

Effects of Selenium in the MAPK Signaling Cascade

Nadereh Rashtchizadeh 1, Pouran Karimi*, Parvin Dehgan 3, Mohamadreza Salimi Movahed 4

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
4 Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: pouran.karimi@yahoo.com

Abstract

Introduction: This study aimed to discover by which mechanism selenium (Se) suppresses stimulated platelets stimulation in oxidative stress underlying diseases.
Methods: Human platelets pretreated with Se and stimulated by Cu2+-oxidized low density of lipoprotein  (OxLDL) or thrombin before assessment of P-selectin and phosphorylated p38 mitogen-activated protein kinase (p-p38MAPK), phosphorylated Jun N-terminal kinase (p–JNK), and phosphorylated extracellular signal-regulated kinases (p-ERK1/2). All variables were measured by solid phase sandwich enzyme-linked immunosorbent assay (ELISA).
Results: Se significantly decreased Cu2+-OxLDL induced P-selectin expression, as well as p38 and JNK phosphorylation in platelets, but could not significantly reduce ERK1/2 phosphorylation.
Conclusion: Se suppresses inflamed platelets. This effect maybe partly mediated by the p38 or c-JNK signaling pathways. These results create possibility of new co-anti-inflammatory insight for Se in atherosclerosis.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1511

Your browser does not support the canvas element.


PDF Download: 851

Your browser does not support the canvas element.