Submitted: 02 Aug 2017
Accepted: 07 Aug 2018
First published online: 10 Sep 2018
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J Cardiovasc Thorac Res. 2018;10(3):162-168.
doi: 10.15171/jcvtr.2018.26
  Abstract View: 159
  PDF Download: 165

Original Article

Effects of a 12-week aerobic exercise on markers of hypertension in men  

Behrouz Baghaiee 1 * , Pouran Karimi 2, Khadije Ebrahimi 3, Saeed Dabagh Nikoo kheslat 4, Mohammad Hossein Sadeghi Zali 5, Amir Mohammad Daneshian Moghaddam 6, Mohammad Sadaghian 7

1 Department of Physical Education and Sports Science, Jolfa Branch, Islamic Azad University, Jolfa, Iran
2 Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Physical Education and Sports Science, Marand Branch, Islamic Azad University, Marand, Iran
4 Department of Exercise Physiology, Faculty of Sport Sciences and Physical Education, University of Tabriz, Tabriz, Iran
5 Department of Microbiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
6 Department of Agriculture, Faculty of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran
7 Department of Pathobiology, Faculty of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran

Article

Introduction: This study was aimed at determining the effects of a 12-week aerobic exercise program on markers of hypertension in men.

Methods: The study was of a semi-experimental design featuring repeated measurements. A total of 40 men (age range=37.9 ± 2.68) with primary hypertension were divided into two groups, namely, the exercise group (n=20) and the control group (n=20) (systolic blood pressure [SBP]: 140.531 ± 0.23, diastolic blood pressure [DBP]: 90.71 ± 0.05). The exercise group participated in a 12-week aerobic exercise program (55% to 70% of HRmax). Blood samples were taken from both groups at the baseline and at the 4th, 8th, and 12th weeks of the training program for the assessment of adiponectin, paraoxonase-1 (PON-1), and hydrogen peroxide (H2 O2 ) levels as the markers for investigation. A linear mixed model was also used to evaluate the association among the markers.

Results: In the exercise group, exercise reduced the SBP and DBP at week 12 (P=0.031 and 0.023, respectively), and adiponectin increased at weeks 8 and 12 (P=0.014 and 0.001, respectively). The plasma PON-1 level showed a significant increase in all the three stages of measurement (P=0.007, 0.004, and 0.002 at weeks 4, 8, and 12, respectively), whereas the H2 O2 levels showed a significant decrease at weeks 8 and 12 (P=0.013 and 0.011, respectively). The control group exhibited significantly decreased PON-1 (P=0.003) and adiponectin (P=0.025) levels but significantly increased SBP at week 12 (P=0.032).

Conclusion: The exercise-induced reduction of oxidative stress exerts a considerable effect on the reduction of blood pressure in hypertensive patients. According to our results increase in oxidative stress has the great impact on the of blood pressure.

Please cite this article as: Baghaiee B, Karimi P, Ebrahimi K, Dabagh Nikoo Kheslat S, Sadeghi Zali MH, Daneshian Moghaddam AM, Sadaghian M. Effects of a 12-week aerobic exercise on markers of hypertension in men. J Cardiovasc Thorac Res 2018;10(3):162-168. doi: 10.15171/jcvtr.2018.26.
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