Submitted: 01 Feb 2016
Revised: 30 Jun 2016
Accepted: 11 Sep 2016
First published online: 30 Sep 2016
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J Cardiovasc Thorac Res. 2016;8(3):113-118.
doi: 10.15171/jcvtr.2016.24
PMID: 27777696
PMCID: PMC5075359
  Abstract View: 585
  PDF Download: 825

Original Article

Effect of remote ischemic post-conditioning on oxidative stress in blood of STEMI patients treated with primary angioplasty

Hassanali Lotfollahi 1,2, Mustafa Mohammadi 1,2 * , Samad Ghaffari 1 * , Reza Badalzadeh 1,2, Bahram Sohrabi 1, Naser Aslanabadi 1, Ahmad Separham 1, Ali Golmohammadi 1, Ali Abbasnejad 1, Mehri Roshani 1

1 Cardiovascular Research Center, Tabriz University of Medical Science, Tabriz, Iran
2 Department of Physiology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran

Abstract

Introduction: This study designed to use remote ischemic post conditioning (RIPC) as a protective strategy during percutaneous coronary intervention (PCI) in patients with ST segment elevation myocardial infarction (STEMI) to reduce myocardial cells damage due to reperfusion injury.
Methods:
Sixty-one patients were divided into test group (32 patients) receiving RIPC and control group (29 patients). Patients were included with first MI who had 20-80 years old. The RIPC protocol was applied on patients arm in three successive episodes during the opening of infarct-related artery (IRA). Whole blood sample were taken from patients after the first episode before IRA opening and after the third episode after IRA opening. The serums were extracted and stored in the freezer -70˚C to determine the levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC) and malondialdehyde (MDA).
Results: The levels of GPX and SOD after the first episode of RIPC were significantly higher in test group than control group (P < 0.001). Similar alterations of these enzymes were obtained after IRA opening (after third episode). In addition, the levels of TAC remained unchanged in control patients but it was significantly increased after the third episode of RIPC in test patients (P < 0.001). Finally, the MDA level was increased in control group in comparison with test group, and administration of RIPC in test group prevented the enhancement of MDA levels significantly (P < 0.001).
Conclusion:
The results indicated that RIPC protocol has protective properties in patients with STEMI through enhancing the antioxidant potentials and decreasing lipid peroxidation.
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