Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 7 4 2015 12 08 Persistent Atrial Septum Defect Despite Placement of Two Amplatzer Septal Occluders 172 174 10.15171/jcvtr.2015.37 EN Kay B. Leissner Jahan Porhomayon Nader D Nader Journal Article 10.15171/jcvtr.2015.37 2015 07 25 Herein, we are presenting a case of persistent interatrial septal defect diagnosed during coronary artery bypass grafting (CABG). Twice, attempts had been made to close this shunt using amplatzer septal occlude. However, percutaneous technique had failed in both occasions. The patient presented with chest pain 4 years after the second attempt and required urgent CABG. Persistent shunt was repaired during surgery.