Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 8 4 2016 12 30 Left ventricular non-compaction in a patient with ankylosing spondylitis 188 189 10.15171/jcvtr.2016.37 EN Mehrnoush Toufan Leili Pourafkari Nader D Nader Journal Article 10.15171/jcvtr.2016.37 2016 06 27 2017 01 04 A 58 years old male with a long-standing history of HLA-B27 positive ankylosing spondylitis presented with increasing fatigue and dyspnea on exertion. He had left ventricular dysfunction and enlargement, flail right coronary leaflet of aortic valve with severe eccentric aortic insufficiency along with left ventricular non-compaction in echocardiography. The most common cardiac manifestations of ankylosing spondylitis are aortic insufficiency and conduction disturbances. Involvement of myocardium, in the form of dilated cardiomyopathy and restrictive cardiomyopathy, has also been reported. This case presents a very rare association of ankylosing spondylitis with non-compaction cardiomyopathy.