Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 10 4 2018 12 16 Unresponsive shock due to amlodipine overdose: An unexpected cause 246 247 10.15171/jcvtr.2018.43 EN Shailesh Kumar Devyani Thakur Ritesh Kumar Gupta Alka Sharma Journal Article 10.15171/jcvtr.2018.43 2017 10 02 2018 11 16 Amlodipine is a dihydropyridine calcium channel blocker which is widely used as an anti-hypertensive drug. Amlodipine overdose has been infrequently reported with the occurrence of serious complications and even death in a few cases. We report an interesting case of a young lady who presented with refractory shock with acute kidney injury, which did not respond to therapy despite optimal fluid replacement and vasopressor support. The etiology of shock could not be ascertained and the patient was questioned again to elucidate the missing clue in the history. It was finally revealed that the patient had consumed 900 mg of amlodipine in a suicide bid, for her poor performance in academics. The targeted therapy in the form of IV calcium and hyperinsulinemia-euglycemia therapy (HIET) was started and the patient dramatically improved with shock reversal and improvement in renal function.