Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 10 2 2018 06 29 Large de novo ascending aortic thrombus successfully treated with anticoagulation 113 114 10.15171/jcvtr.2018.18 EN Mustafa Houmsse Asia McDavid Ahmet Kilic Journal Article 10.15171/jcvtr.2018.18 2017 10 25 2018 04 27 An ascending aortic thrombus is a rare source for embolic transient ischemic attack (TIA) or stroke without an associated aortic pathology. Here we describe a case of a patient who presented with generalized symptoms of headache and fatigue who, on subsequent work-up, was found to have an ascending aortic thrombus with no obvious associated aortic pathology, and was successfully treated with apixaban, a newer direct oral anticoagulant.