Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 3 1 2011 04 04 Proteinuria in Congenital Heart Disease: Is It a Real Problem? 17 21 EN Majid Maleki Shamsi Ghaffari Mohammad Reza Ghaffari Mahmood Samadi Bahman Rastkar Pooya Maleki Sahar Behnam Journal Article 2010 11 27 The relationship between congenital heart disease and nephropathy has been known for a long time although its mechanism has not been understood thoroughly. Furthermore such studies have been performed in older populations. 74 children aged between two months to 168 months (20 normal as control group, 20 cyanotic and 34 acyanotic patients with congenital heart disease were investigated for their renal function and protein excretion. The data were analyzed using SPSS (version 16.1) independent t- test. Creatinine and glomerular filtration rate in cyanotic was lower than acyanotic group but these were not significant while both protein excretion incidence (65% vs 24%) and quantity (1.2 vs 0.2; measured as urine protein to creatinine ratio) were higher significantly in cyanotic group (P< 0. 001). In cyanotic children with congenital heart disease proteinuria is more common and more severe compared with acyanotic patients; this is not related to age in children as it may occur in the same nephrotic range in infants with cyanotic congenital heart disease.