Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 13 1 2021 02 28 Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study 79 83 10.34172/jcvtr.2021.06 EN Farzad Kakaei https://orcid.org/0000-0003-1632-7393 Saba Mirabolfathi Negin Yavari Mohammad Reza Ardalan Mehrdad Mozafar Sina Zarrintan https://orcid.org/0000-0002-3968-0221 Journal Article 10.34172/jcvtr.2021.06 2019 10 21 2020 12 14 Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis. Methods: In this cross-sectional study, 60 consecutive patients with ESRD on HD with tunneled cuffed catheters were selected. Inherited thrombophilia factors (Anti-thrombin III, Protein C, Protein S, and Factor V Leiden) were measured and the patients were followed for 3 months to evaluate the incidence of catheter-related thrombosis. The association between these factors and catheter thrombosis was assessed. Results: The mean age of patients was 60.30 ± 8.69 years. Forty-seven patients (78.30%) were female and thirteen patients (21.70%) were male. The most common cause of ESRD was diabetes mellitus (41.67%). The most catheter site was the right internal jugular vein (55%). There were 22 (36.67%) and 8 (13.33%) cases of thrombosis and mortality, respectively. The association between hereditary thrombophilia factors and catheter thrombosis was not statistically significant (P > 0.05). Conclusion: In this small group of our patients, the frequency of hereditary thrombophilia was not significantly different between those with and without thrombosis of tunneled HD catheter.