Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 12 3 2020 09 05 Vascular calcification; Stony bridge between kidney and heart 165 171 10.34172/jcvtr.2020.29 EN Behzad Zaker https://orcid.org/0000-0003-4953-5770 Mohammadreza Ardalan https://orcid.org/0000-0002-6851-5460 REVIEW 10.34172/jcvtr.2020.29 2019 11 24 2020 07 10 Vascular calcification is a high prevalent complication that arises as a consequence of impaired calcium and phosphate balance amongst cardiovascular patients. Multiple inducer/ inhibitory molecules and pathways as well as genetic background and lifestyle play role in this phenomenon. According to which vessel layer (intima, media or both) is involved different types of vascular calcification take place. Actual mechanism and consensus pathways have not been elucidated yet and needs further investigations