Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 12 3 2020 09 05 Prevalence of the prothrombin G20210A mutation among ischemic stroke patients 227 230 10.34172/jcvtr.2020.39 EN Salar A. Ahmed https://orcid.org/0000-0002-0417-7984 Sazgar A. Hameed Bashdar M. Hussen https://orcid.org/0000-0003-1060-6527 Abbas Salihi https://orcid.org/0000-0002-1342-2849 Journal Article 10.34172/jcvtr.2020.39 2020 01 31 2020 08 11 Introduction: Ischemic stroke is characterized as a sudden neurological deficit attributed to an acute focal injury of the central nervous system by a vascular cause. This study was performed to determine the frequency of G20210A mutation in the prothrombin gene and its effectiveness on the incidence of ischemic stroke in the Erbil city of Kurdistan region, Iraq. Methods: A total of 50 patients with ischemic stroke was analyzed for the detection of prothrombin gene mutation (G20210A), using polymerase chain reaction (PCR), Restriction fragment length polymorphism (RFLP) with Hind III restriction enzyme. Results: We observed no evidence of an association between ischemic stroke and G20210A mutation in the prothrombin gene in this region. Conclusion: Our finding demonstrates that prothrombotic gene variant seems not to be linked to the incidence of ischemic stroke in Erbil region.