Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 12 4 2020 12 16 Association of rs4618210A>G variant in PLCL2 gene with myocardial infarction: A case-control study in Iran 303 306 10.34172/jcvtr.2020.49 EN Najmeh Ramezanpour https://orcid.org/0000-0003-0820-4983 Mahboobeh Nasiri https://orcid.org/0000-0003-1370-6849 Omid Reza Akbarpour Journal Article 10.34172/jcvtr.2020.49 2020 06 06 2020 10 20 Introduction: Myocardial infarction (MI) is the leading cause of death all over the world. The pivotal roles of Phospholipase C like 2 gene (PLCL2) in calcium homeostasis and immune responses make this gene as a potential candidate for its role in MI pathogenesis. The present study was undertaken to investigate whether rs4618210A>G polymorphism in PLCL2 gene contribute to MI etiology. Methods: A hospital-based case-control study with 600 subjects, including 300 MI patients and 300controls, was conducted. Genotyping of PLCL2 rs4618210 polymorphism was performed using amplification refractory mutation system-polymerase chain reaction (ARMS PCR) method. Data were analyzed using logistic regression analysis. Results: No significant association was found between the PLCL2 rs4618210 alleles and MI risk.However, a significantly increased risk of MI was observed among carriers of the AG genotype (OR= 1.91; 95% CI = 1.24 - 2.93; P = 0.003) compared with AA homozygote. In a dominant mode of inheritance for G allele (GG + AG vs. AA), the frequency of the carriers of at least one G allele was higher in cases compared to controls (OR= 1.56; 95% CI: 1.03 – 2.36; P = 0.037). Conclusion: Our study provided further evidence that PLCL2 gene polymorphism may serve as a prognostic marker for MI.