Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 13 1 2021 02 28 Demystifying penetrating atherosclerotic ulcer of aorta: unrealised tyrant of senile aortic changes 1 14 10.34172/jcvtr.2021.15 EN Rahul Dev https://orcid.org/0000-0002-0072-9059 Khorwal Gitanjali https://orcid.org/0000-0002-1541-1764 Darbari Anshuman https://orcid.org/0000-0002-4524-2359 REVIEW 10.34172/jcvtr.2021.15 2020 11 06 2021 01 09 This review article describes demographic features, comorbidities, clinical and imaging findings, prognosis, and treatment strategies in penetrating atherosclerotic ulcer (PAU) and closely related entities using google scholar web search. PAU is one of the manifestations of the acute aortic syndrome (AAS) spectrum. The underlying aorta invariably shows atherosclerotic changes or aneurysmal dilatation. Hypertension is the most common contributing factor, with chest or back pain being the usual manifestation. Intramural hematoma (IMH) is the second entity associated with both PAU and aortic dissection (AD), more so with the latter. Chest radiograph can show mediastinal widening, pleural, or pericardial fluid in rupture. Computed tomography angiography (CTA) is the imaging modality of choice to visualize PAU, with magnetic resonance imaging (MRI) and transoesophageal echocardiography (TEE) adding diagnostic value. Lesser-known entities of intramural blood pool (IBP), limited intimal tears (LITs), and focal intimal disruptions (FID) are also encountered. PAU can form fistulous communication with adjacent organs whereas IMH may propagate to dissection. CTA aids in defining the management, open or endovascular options in surgical candidates.