Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 13 4 2021 12 12 Characteristics and outcomes of hospitalized patients with cardiovascular complications of COVID-19 355 363 10.34172/jcvtr.2021.53 EN Farzad Jalali https://orcid.org/0000-0001-6896-4816 Farbod Hatami https://orcid.org/0000-0002-8738-6799 Mehrdad Saravi https://orcid.org/0000-0001-7499-3437 Iraj Jafaripour https://orcid.org/0000-0002-2702-1747 Mohammad Taghi Hedayati https://orcid.org/0000-0003-2344-2365 Kamyar Amin https://orcid.org/0000-0002-5111-2059 Roghayeh Pourkia https://orcid.org/0000-0002-8013-7888 Saeid Abroutan Mostafa Javanian https://orcid.org/0000-0002-2771-4578 Soheil Ebrahimpour https://orcid.org/0000-0003-3204-0448 Niloufar Valizadeh https://orcid.org/0000-0002-6092-7073 Saeede Khosravi Bizhaem https://orcid.org/0000-0002-6087-2922 Naghmeh Ziaie https://orcid.org/0000-0003-4933-8240 Journal Article 10.34172/jcvtr.2021.53 2021 05 09 2021 11 24 Introduction: To address cardiovascular (CV) complications and their relationship to clinical outcomes in hospitalized patients with COVID-19. Methods: A total of 196 hospitalized patients with COVID-19 were enrolled in this retrospective single-center cohort study from September 10, 2020, to December 10, 2020, with a median age of 65 years (IQR, 52-77). Follow-up continued for 3 months after hospital discharge. Results: CV complication was observed in 54 (27.6%) patients, with arrhythmia being the most prevalent (14.8%) followed by myocarditis, acute coronary syndromes, ST-elevation myocardial infarction, cerebrovascular accident, and deep vein thrombosis in 15 (7.7%), 12 (6.1%), 10(5.1%), 8 (4.1%), and 4 (2%) patients, respectively. The proportion of patients with elevated high-sensitivity troponin I, N-terminal pro-B-type natriuretic peptide, left ventricular diastolic dysfunction, and heart failure with preserved ejection fraction was greater in the CV complication group. Severe forms of COVID-19 comprised nearly two-thirds (64.3%) of our study population and constituted a significantly higher share of the CV complication group members (75.9%vs 59.9%; P=0.036). Intensive care unit admission (64.8% vs 44.4%; P=0.011) and stay (5.5days vs 0 day; P=0.032) were notably higher in patients with CV complications. Among 196patients, 50 died during hospitalization and 10 died after discharge, yielding all-cause mortality of 30.8%. However, there were no between-group differences concerning mortality. Age, heart failure, cancer/autoimmune disease, disease severity, interferon beta-1a, and arrhythmia were the independent predictors of all-cause mortality during and after hospitalization. Conclusion: CV complications occurred widely among COVID-19 patients. Moreover,arrhythmia, as the most common complication, was associated with increased mortality.