Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 14 2 2022 06 30 A glance at the application of CRISPR/Cas9 gene-editing technology in cardiovascular diseases 77 83 10.34172/jcvtr.2022.14 EN Neda Roshanravan https://orcid.org/0000-0002-8173-6532 Helda Tutunchi Farzad Najafipour Mohammadreza Dastouri https://orcid.org/0000-0003-3882-0728 Samad Ghaffari https://orcid.org/0000-0001-6806-9387 Alireza Jebeli REVIEW 10.34172/jcvtr.2022.14 2022 02 28 2022 05 21 Cardiovascular diseases (CVDs) remain major causes of global mortality in the world. Genetic approaches have succeeded in discovery of the molecular basis of an increasing number of cardiac diseases. Genome editing strategies are one of the most effective methods for assisting therapeutic approaches. Potential therapeutic methods of correcting disease-causing mutations or of knocking out specific genes as approaches for the prevention of CVDs have gained substantial attention using genome editing techniques. Recently, the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system has become the most widely used genome-editing technology in molecular biology due to its benefits such as simple design, high efficiency, good repeatability, short-cycle, and costeffectiveness. In the present review, we discuss on the possibilities of applying the CRISPR/Cas9 genome editing tool in the CVDs.