Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 14 4 2022 12 31 Predictive value of C-reactive protein/albumin ratio for no-reflow in patients with non-ST-elevation myocardial infarction 214 219 10.34172/jcvtr.2022.30549 EN Aydın Rodi Tosu https://orcid.org/0000-0002-4588-8993 Tufan Çinar https://orcid.org/0000-0001-8188-5020 Muhsin Kalyoncuoğlu Halil İbrahim Biter Sinem Çakal Beytullah Çakal Murat Selçuk Erdal Belen Mehmet Mustafa Can Journal Article 10.34172/jcvtr.2022.30549 2022 04 06 2022 10 13 Introduction: The focus of this research was to explore the link between CRP (C-reactive protein) /albumin ratio (CAR), a novel inflammatory response marker, and no-reflow (NR) phenomena in non-ST elevation myocardial infarction (non-STEMI) patients during percutaneous coronary intervention (PCI). Methods: The current study recruited 209 non-STEMI participants who underwent PCI. The patients were divided into two groups based on their post-intervention Thrombolysis in Myocardial Infarction (TIMI) flow grade; those with and without NR. Results: In all, 30 non-STEMI patients (6.9%) had NR after PCI. CAR values were substantially greater in the NR group. The CAR was identified to be a determinant of the NR (OR: 1.250, 95% CI: 1.033-1.513, P=0.02), although CRP and albumin were not independently related with NR in the multivariate analysis. In our investigation, low density lipoprotein-cholesterol levels and high thrombus burden were also predictors of the occurrence of NR. According to receiver operating characteristic curve evaluation, the optimal value of CAR was>1.4 with 60% sensitivity and 47% specificity in detecting NR in non-STEMI patients following PCI. Conclusion: To the best of knowledge, this is the first investigation to demonstrate that the CAR, a new and useful inflammatory marker, can be utilized as a predictor of NR in patients with non-STEMI prior to PCI.