Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 15 2 2023 06 29 Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine 68 72 10.34172/jcvtr.2023.31830 EN Neda Roshanravan https://orcid.org/0000-0002-8173-6532 Samad Ghaffari https://orcid.org/0000-0001-6806-9387 Sepideh Bastani Sara Pahlavan Samira Asghari Mohammad Amin Doustvandi Sepideh Jalilzadeh- Razin Mohammadreza Dastouri https://orcid.org/0000-0003-3882-0728 REVIEW 10.34172/jcvtr.2023.31830 2023 04 04 2023 06 10 Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine.