Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 16 2 2024 06 25 Association of H-FABP with cardiovascular events: A systematic review 77 87 10.34172/jcvtr.33039 EN Ambili Parekumbel Venu https://orcid.org/0009-0005-6220-2382 Rajamanickam Rajkumar https://orcid.org/0000-0003-4904-8884 Divakaran Dinesh Roy https://orcid.org/0009-0005-7124-148X Sreelal Thekkumkara Prabhakaran Kanagasabapathy Shankar Vidhyadharan Jayapal Sureka Varalakshmi Sreeja Sreenivasan REVIEW 10.34172/jcvtr.33039 2023 12 10 2024 05 04 The research aimed to evaluate the association between heart-type fatty acid binding protein (H-FABP) and cardiovascular events. We systematically reviewed research that has been conducted to assess this relationship, aiming to determine how useful H-FABP could be as a biomarker for cardiovascular diseases, especially in the initial phases of acute myocardial infarction (AMI) and acute coronary syndrome (ACS). Our goal was to validate its diagnostic accuracy and clinical relevance. We systematically searched through PubMed, Web of Science, and Google Scholar databases to find pertinent publications related to cardiovascular diseases and H-FABP, using various permutations, abbreviations, and language variations of MeSH keywords. The final analysis included 12 studies in total. The final study comprised twelve studies, and it was concluded that H-FABP demonstrated high sensitivity (64.3-91.5) and specificity (73-100) for diagnosing Acute Myocardial Infarction (AMI) and Acute Coronary Syndrome (ACS), especially within the first hours of symptom onset. H-FABP demonstrates potential in enhancing the overall diagnostic accuracy during the initial hours following the manifestation of symptoms. However, the existing data do not provide sufficient evidence to recommend the regular utilization of H-FABP as a preliminary risk assessment approach in individuals who present with suspected cardiac events. Additional investigations, with well-defined prospective cohorts, are needed to validate the results observed.