Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 16 4 2024 12 23 Association between small dense low-density lipoprotein and carotid intima-media thickness 202 210 10.34172/jcvtr.33145 EN Mohsen Khosravi https://orcid.org/0000-0001-9815-7695 Farhad Sheikhnia Mohammad Reza Pashaei Maryam Karimi-Dehkordi Shahin Alizadeh-Fanalou https://orcid.org/0000-0003-0448-7074 REVIEW 10.34172/jcvtr.33145 2024 04 07 2024 10 05 Cardiovascular disease (CVD) and atherosclerosis are major causes of mortality worldwide. Early and accurate diagnosis of vascular thickening by predictive markers can help reduce the death rate of these diseases. Low-density lipoprotein (LDL) particles, which are rich in cholesterol, are regarded as key biomarkers for CVD and atherosclerosis. Numerous studies have demonstrated that pattern B (small dense LDL, sdLDL) is more atherogenic than LDL and can serve as a superior quantitative marker for CVD than LDL. Furthermore, several studies have indicated that carotid intima-media thickness (cIMT) is a reliable marker for the early detection of CVD and atherosclerosis in various populations. This review examines the relationship between sdLDL concentration and cIMT. It is concluded that sdLDL concentration has a positive correlation with cIMT, and their combined use can facilitate a more precise assessment of the diseases, especially atherosclerosis.