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J Cardiovasc Thorac Res. 2019;11(3): 189-195. doi: 10.15171/jcvtr.2019.32
PMID: 31579458        PMCID: PMC6759611

Original Article

Chronic dosing with metformin plus bosentan decreases in vitro pulmonary artery contraction from isolated arteries in adults with pulmonary hypertension

Shutan Liao 1,2 ORCID, Dongsheng Li 3, Zheng Hui 2, Craig S McLachlan 1, Yang Zhang 3 * ORCID

Cited by CrossRef: 8


1- Bu Y, Peng M, Tang X, Xu X, Wu Y, Chen A, Yang X. Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms. J Cellular Molecular Medi. 2022;26(19):4886 [Crossref]
2- Xiao F, Zhang R, Wang L. Inhibitors of Mitochondrial Dynamics Mediated by Dynamin-Related Protein 1 in Pulmonary Arterial Hypertension. Front Cell Dev Biol. 2022;10 [Crossref]
3- Zhao Q, Song P, Zou M. AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling. Front Cell Dev Biol. 2021;9 [Crossref]
4- António T, Soares-da-Silva P, Pires N, Gomes P. Salt-inducible kinases: new players in pulmonary arterial hypertension?. Trends in Pharmacological Sciences. 2022;43(10):806 [Crossref]
5- Yang Y, Lin F, Xiao Z, Sun B, Wei Z, Liu B, Xue L, Xiong C. Investigational pharmacotherapy and immunotherapy of pulmonary arterial hypertension: An update. Biomedicine & Pharmacotherapy. 2020;129:110355 [Crossref]
6- Liu R, Yuan T, Wang R, Gong D, Wang S, Du G, Fang L. Insights into Endothelin Receptors in Pulmonary Hypertension. IJMS. 2023;24(12):10206 [Crossref]
7- Abdelazeem H, Tu L, Thuillet R, Ottaviani M, Boulfrad A, Beck T, Senbel A, Mani S, Castier Y, Guyard A, Tran-Dinh A, El-Benna J, Longrois D, Silverstein A, Guignabert C, Norel X. AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery. European Journal of Pharmacology. 2023;946:175579 [Crossref]
8- Abdelazeem H, Tu L, Thuillet R, Ottaviani M, Boulfrad A, Senbel A, Mani S, Castier Y, Guyard A, Tran-Dinh A, El-Benna J, Longrois D, Silverstein A, Guignabert C, Norel X. AMPK Activation Protects Against Pulmonary Hypertension in Rats and Relaxes Isolated Human Pulmonary Artery. SSRN Journal. 2022; [Crossref]