Submitted: 14 Oct 2017
Accepted: 16 Sep 2018
First published online: 27 Sep 2018
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J Cardiovasc Thorac Res. 2018;10(3):129-137.
doi: 10.15171/jcvtr.2018.21
PMID: 30386532
PMCID: PMC6203867
  Abstract View: 538
  PDF Download: 283

Review Article

New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota

Jalal Moludi 1,2, Mohammad Alizadeh 1 * , Ned Lotfi Yagin 1, Yahiya Pasdar 3, Seyed Mostafa Nachvak 3, Hadi Abdollahzad 3, Ali Sadeghpour Tabaei 4

1 Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2 Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
3 Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran


The incidence of atherosclerosis is increasing rapidly all over the world. Inflammatory processes have outstanding role in coronary artery disease (CAD) etiology and other atherosclerosis manifestations. Recently attentions have been increased about gut microbiota in many fields of medicine especially in inflammatory diseases like atherosclerosis. Ineffectiveness in gut barrier functions and subsequent metabolic endotoxemia (caused by rise in plasma lipopolysaccharide levels) is associated with low-grade chronic inflammation i.e. a recognized feature of atherosclerosis. Furthermore, the role of trimethylamine-N-oxide (TMAO), a gut bacterial metabolite has been suggested in atherosclerosis development. On the other hand, the effectiveness of gut microbiota modulation that results in TMAO reduction has been investigated. Moreover, considerable evidence supports a role for the endocannabinoid system (ECS) in atherosclerosis pathology which affects gut microbiota, but their effects on atherosclerosis are controversial. Therefore, we presented some evidence about the relationship between gut microbiota and ECS in atherosclerosis. We also presented evidences that gut microbiota modulation by pre/probiotics can have significant influence on the ECS.
Please cite this article as: Moludi J, Alizadeh M, Lotfi Yagin N, Pasdar Y, Nachvak SM, Abdollahzad H, Sadeghpour Tabaei A. New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota. J Cardiovasc Thorac Res 2018;10(3):129-137. doi: 10.15171/jcvtr.2018.21.
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