Submitted: 02 May 2017
Accepted: 24 Nov 2017
ePublished: 25 Dec 2017
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J Cardiovasc Thorac Res. 2017;9(4): 215-220.
doi: 10.15171/jcvtr.2017.37
PMID: 29391935
PMCID: PMC5787334
  Abstract View: 918
  PDF Download: 619

Original Article

The frequency and importance of chest pain in midterm follow up of transcatheter closure of interatrial septal defect

Azin Alizadehasl 1, Mohsen Neshati Pir Borj 1, Anita Sadeghpour 1, Ata Firouzi 1 * , Hamidreza Sanati 1, Masoud Movassaghi 2

1 Echocardiography Research Center, Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Department of Pathology and Laboratory Medicine, University of California-Los Angeles (UCLA), Los Angeles, California, USA


Introduction: We evaluated chest pain alongside other midterm subjective and objective complications of the transcatheter closure of atrial septal defects (ASDs) and patent foramen ovales (PFOs) with various closure devices.
Methods: This cross-sectional study, performed from March 2010 to October 2015 in Rajaie Cardiovascular, Medical, and Research Center, evaluated 313 patients (mean age = 29.12 ± 10 years, 32.9% male) for probable complications associated with the transcatheter occlusion of secundum ASDs (n = 289, mean age = 30.5 ± 11.4 years, 28% male) or PFOs (n = 24, mean age = 42.8 ± 10.2 years). ASD closure was performed under sedation and transesophageal echocardiography (TEE) guidance. Duration of follow-up was 12 ± 3 months (mean follow-up = 11.52 months).
Results: Among the subjective complications, chest pain was the most frequent complaint during the follow-up period and although it was common (7.3%), a clear cardiac etiology was rare. Thirteen (4.2%) patients reported palpitation during the follow-up period, and 4 had documented arrhythmias—including atrial flutter, atrial fibrillation, and 2:1 atrioventricular block. Migraine with or without aura occurred in 1.6% of the patients. Objective complications comprising tamponade, device embolization, and thrombus formation occurred in 6 (1.9%) patients. There was no procedure-related mortality in our patients.
Conclusion: Transcatheter closure of PFOs and secundum-type ASDs in our adult patients using ASD septal occluders was associated with a high degree of success, minimal procedural subjective and objective complication rates, and excellent short- and midterm results. Although chest pain was common after the first month following ASD closure, there was no cardiac death or aortic erosion in 11.52 months follow up.
Keywords: Transcatheter Closure, Secundum Atrial Septal Defect, Chest pain, Patent Foramen Ovale, Complications, Transesophageal Echocardiography
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