Logo-jcvtr
Submitted: 04 Apr 2017
Revision: 25 Sep 2017
Accepted: 30 Sep 2017
ePublished: 30 Sep 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Cardiovasc Thorac Res. 2017;9(3): 170-174.
doi: 10.15171/jcvtr.2017.29
PMID: 29118951
PMCID: PMC5670340
  Abstract View: 1305
  PDF Download: 916

Original Article

Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease

Nahid Shahmoradi 1, Mahboobeh Nasiri 1*, Hajar Kamfiroozi 2, Mohammad Ali Kheiry 3

1 Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
2 Department of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran
3 Internist-Cardiologist, Private Dr. Kheiry Clinic, Neyriz, Fars, Iran
*Corresponding Author: Email: nasiri@iaua.ac.ir

Abstract

Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This study aimed to investigate the association between SENCR rs555172 polymorphism and CAD in south Iranian population.
Methods: Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was performed to determine the allele and the genotype distribution of SENCR lncRNA polymorphism in 150 patients with CAD compared with 149 healthy controls through this hospital-based case-control study.
Results: The frequency of AA, AG, and GG genotypes in cases were 32.7%, 44.7%, and 22.6%, and in controls were 26.8%, 49%, and 24.2%, respectively. Association was not found with any of the genotypes in comparison of cases and controls. The allelic frequencies did not differ between cases and controls. Cross-tabulating the population based on the gender, the frequency of the GG genotype was significantly higher among women of the case group compared to men. The difference was not seen in the control group between two sexes.
Conclusion: The results suggested that the SENCR gene polymorphism did not confer susceptibility to CAD.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1306

Your browser does not support the canvas element.


PDF Download: 916

Your browser does not support the canvas element.