Submitted: 02 Oct 2017
Revised: 19 Sep 2018
Accepted: 16 Nov 2018
First published online: 05 Dec 2018
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J Cardiovasc Thorac Res. 2018;10(4):246-247.
doi: 10.15171/jcvtr.2018.43
  Abstract View: 312
  PDF Download: 182

Case Report

Unresponsive shock due to amlodipine overdose: An unexpected cause

Shailesh Kumar 1, Devyani Thakur 1, Ritesh Kumar Gupta 1, Alka Sharma 1 *

1 Department of Medicine, Dr RML Hospital and PGIMER, Delhi, India

Abstract

Amlodipine is a dihydropyridine calcium channel blocker which is widely used as an anti-hypertensive drug. Amlodipine overdose has been infrequently reported with the occurrence of serious complications and even death in a few cases. We report an interesting case of a young lady who presented with refractory shock with acute kidney injury, which did not respond to therapy despite optimal fluid replacement and vasopressor support. The etiology of shock could not be ascertained and the patient was questioned again to elucidate the missing clue in the history. It was finally revealed that the patient had consumed 900 mg of amlodipine in a suicide bid, for her poor performance in academics. The targeted therapy in the form of IV calcium and hyperinsulinemia-euglycemia therapy (HIET) was started and the patient dramatically improved with shock reversal and improvement in renal function.
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