Majid Maleki
1, Shamsi Ghaffari
2, Mohammad Reza Ghaffari
3, Mahmood Samadi
2, Bahman Rastkar
2, Pooya Maleki
4, Sahar Behnam
41 Department of Paediatric Nephrology, Tabriz Children’s Hospital, Tabriz University ofMedical Sciences , Tabriz, Iran.
2 Cardiovascular ResearchCenter, Tabriz University ofMedical Sciences, Tabriz, Iran.
3 Department of Tuberculosis and Pulmonary Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran.
4 Hormozgan University of Medical Sciences,Vali Asr Hospital ,Queshm,Iran.
Abstract
The relationship between congenital heart disease and nephropathy has been known for a
long time although its mechanism has not been understood thoroughly. Furthermore such
studies have been performed in older populations. 74 children aged between two months
to 168 months (20 normal as control group, 20 cyanotic and 34 acyanotic patients with
congenital heart disease were investigated for their renal function and protein excretion.
The data were analyzed using SPSS (version 16.1) independent t- test. Creatinine and
glomerular filtration rate in cyanotic was lower than acyanotic group but these were not
significant while both protein excretion incidence (65% vs 24%) and quantity (1.2 vs 0.2;
measured as urine protein to creatinine ratio) were higher significantly in cyanotic group
(P< 0. 001). In cyanotic children with congenital heart disease proteinuria is more
common and more severe compared with acyanotic patients; this is not related to age in
children as it may occur in the same nephrotic range in infants with cyanotic congenital
heart disease.