Evaluation of hs-CRP, Antioxidant Markers andMDA in Patients of Coronary Artery Disease (CAD) Containing Non-Smokers and Non-Diabetics

Abstract

Background: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study we assessed the association of MDA, antioxidant markers, high sensitive C - reactive protein (hs-CRP) and lipid status parameters in the patients with coronary artery disease (CAD). Significant risk factors such as cigarette and diabet were excluded from the study. Methods: Oxidative stress parameters for example Malondialdehyde (MDA), antioxidant markers including: erythrocyte superoxide dismutase(SOD), Glutathion peroxidase (GPX), Total antioxidant capacity(TAC), The inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients with angiographically diagnosed CAD and 60 CAD-free subjects as a control group, also diabetics, smoking patients, patients with malignancy, renal and liver disease, and other disease were excluded from the study. Results: The serum MDA and hs-CRP levels were increased significantly as compared to controls. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (P‹0.05 in all cases). The levels of total cholesterol, Triglyceride, LDL-C were significantly higher and that of HDL-C was meaningfully lower than those of control (P‹0.05 in all cases). Conclusion: The association between oxidative stress parameters, antioxidant markers, the inflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression

Keywords: Antioxidant, Oxidative stress, Coronary Artery Disease, Inflammation, Nonsmoker, Nondiabetic