Comparison of serum Homocysteine concentrations between smoker and nonsmoker patients with acute coronary syndrome in Tabriz ShahidMadani Hospital during 2008-2009

Abstract

Background: According to previous studies elevated blood total homosyteine has been suggested to be an independent risk factor for cardiovascular disease. The aim of this study was evaluation of homosyteine serum in smoker and nonsmoker patients with acute coronary syndrome (ACS). Methods: Eighty five patients were enrolled in this study .Forty eight patients (21smoker and 27non-smoker) diagnosed with acute myocardial infarction (AMI), 37 patients (14smoker and 23non-smoker) with unstable angina (UA) that admitted in Shahid Madani Heart center in Tabriz in 2008-2009. The mean age of patients with AMI and UA were 61.83±13.78 and 59.90±11.95 years, respectively. Homocysteine serum Levels were measured by Hitachi Auto analyzer. Results: The mean age of patients with AMI was 61.83±13.78 years and in patients with UA was 59.90±11.95 years (p=0.53). Mean serum levels of homocysteine were not significant difference between AMI and UA patients (17.61±11.25 μmol/L vs. 22.25±12.44, p=0.78). There was also a significant correlation between high levels of homocysteine with AMI and UA diseases in comparison with normal reference values. There were not statistically significant differences in serum homocysteine levels between smoker and nonsmoker patients in both AMI and UA groups. Conclusion: The Mean levels of Homocysteine in AMI and UA groups were not significantly different. Our study showed age of smoker patients in AMI and UA groups were significantly lower than nonsmoker patients

Keywords: Homocysteine, Acute Coronary Syndrome, Smoking