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Submitted: 10 Apr 2013
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J Cardiovasc Thorac Res. 2013;5(2):67-70.
doi: 10.5681/jcvtr.2013.014
PMID: 24251014
PMCID: PMC3825383
  Abstract View: 447
  PDF Download: 368

Original Article

Effect of a Probiotic Preparation (VSL#3) on Cardiovascular Risk Parameters in Critically-Ill Patients

Sarvin Sanaie 1, Mehrangiz Ebrahimi-Mameghani 2 * , Ata Mahmoodpoor 3, Kamran Shadvar 3, Samad EJ Golzari 4,5

1 Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2 Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
3 Anesthesiology and Intensive Care Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Cardiovascular disease (CVD) counts for a major portion of morbidity and mortality globally mostly accompanied by lipid abnormalities. Being at increased risk of cardiac injury, critically ill patients suffer from various lipid disorders. Lipid homeostasis has been efficiently restored by the introduction of probiotics. The aim of this trial was to determine the effect of probiotics on inflammation, antioxidant capacity and lipid peroxidation in critically ill patients. Methods: Forty patients admitted to the intensive care unit were randomized to receive placebo or probiotic for 7 days. Serum levels of triglyceride (TG), total cholesterol, HDL-C, LDL-C and high- sensitivity C-reactive protein (hs-CRP) were measured before initiation of the study and on the 7th day. Results: There was a significant difference between two groups regarding the levels of TG, HDL and hs-CRP at the end of the study (P= 0.043, <0.001 and 0.003, respectively); however, there was not a significant difference in total cholesterol and LDL-C levels. Conclusion: Administration of probiotics in critically ill patients reduced the levels of TG and hs-CRP and increased HDL-C levels. However, no significant change was detected in levels of total cholesterol or LDL-C.
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