Submitted: 02 Sep 2018
Revision: 26 Sep 2018
Accepted: 30 Sep 2018
ePublished: 13 Dec 2018
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J Cardiovasc Thorac Res. 2018;10(4): 236-242.
doi: 10.15171/jcvtr.2018.41
PMID: 30680084
PMCID: PMC6335981
  Abstract View: 595
  PDF Download: 374

Original Article

Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy

Mehrnoush Toufan Tabrizi 1, Roghaieh Rahimi Asl 1, Soheyla Nazarnia 1, Leili Pourafkari 1 *

1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction: Morphology of bicuspid aortic valve (BAV) may have implication in the associated pathologies including aortic stenosis (AS), aortic insufficiency (AI) and aortic dilation. The aim of this study is to investigate the frequency and patterns of valvular dysfunction and aortopathy associated with different phenotypes of BAV in a referral center in northwest of Iran.
Methods: In this prospective study patients who presented to our echocardiography lab between January 2014 and December 2015 and were diagnosed with BAV were assessed. Frequency of various BAV phenotypes and their association with valvular dysfunction and aortopathy was evaluated. A P value less than 0.05 was considered statistically significant.
Results: The average age of the study patients was 40±16 years, with predominance of male sex (72%). Patients with anteroposteriorly located BAV (BAV-AP) phenotype constituted majority of our cases with prevalence of 62.7%, while 37.3% of cases had right-left (BAV-RL) located valves. BAV-RL patients when compared to BAV-AP patients had higher frequencies of dilated aortic arch (25% vs. 4.3%, P < 0.001), AS (56.3% vs. 31.4%, P < 0.001), mass or vegetation on aortic valve (14.3 vs. 6.4%, P = 0.023) and lower frequencies of dilated aortic root (42.9% vs. 57.4%, P = 0.01), aortic insufficiency (68.8% vs. 79.8%, P = 0.034) and co-arctation of aorta (3.6% vs. 11.7%, P = 0.01).
Conclusion: There seems to be a relationship between various BAV phenotypes, and frequency and pattern of aortic valve dysfunction and aortopathy. These findings suggest that examining leaflet morphology in BAV might help in risk stratification of these patients.
Keywords: Bicuspid Aortic Valve, Valvular Dysfunction, Aortopathy
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