Submitted: 13 Jan 2019
Accepted: 04 Oct 2019
ePublished: 24 Oct 2019
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J Cardiovasc Thorac Res. 2019;11(4): 318-321.
doi: 10.15171/jcvtr.2019.52
PMID: 31824615
PMCID: PMC6891042
  Abstract View: 240
  PDF Download: 133

Short Communication

Prognostic value of normal and non-obstructive coronary artery disease based on CT angiography findings. A 12 month follow up study

Amirreza Sajjadieh Khajouei 1, Atoosa Adibi 1, Zahra Maghsodi 1, Majid Nejati 2, Mohaddeseh Behjati 3 * ORCID logo

1 Al-Zahra hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
3 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran


Introduction: The advent of multi-slice computed tomography (CT) technology has provided a new promising tool for non-invasive assessment of the coronary arteries. However, as the prognostic outcome of patients with normal or non-significant finding on computed tomography coronary angiography (CTCA) is not well-known, this study was aimed to determine the prognostic value of CTCA in patients with either normal or non-significant CTCA findings.|
Methods: This retrospective cohort study was performed on patients who were referred for CTCA to the hospital. 527 patients with known or suspected coronary artery disease (CAD), who had undergone CTCA within one year were enrolled. Among them, data of 465 patients who had normal (no stenosis, n=362) or non-significant CTCA findings (stenosis <50% of luminal narrowing, n=103) were analyzed and prevalence of cardiac risk factors and major adverse cardiac events (MACE) were compared between these groups. In addition, a correlation between these factors and the number of involved coronary arteries was also determined.
Results: After a mean follow-up duration of 13.11±4.63 months, all cases were alive except for three patients who died by non-cardiac events. Prevalence of MACE was 0% and 3% in normal CTCA group and non-significant groups, respectively. There was no correlation found between the number of involved coronary arteries and the prevalence of MACE (P = 0.57).
Conclusion: A normal CTCA could be associated with extremely low risk of MACE over the first year after the initial imaging, whereas non-significant obstruction in coronary arteries may be associated with a slightly higher risk of MACE.
Keywords: Computed Tomography, Angiography, Coronary Disease, Prognostic Value
Please cite this article as: Sajjadieh Khajouei A, Adibi A, Maghsodi Z, Nejati M, Behjati M. Prognostic value of normal and nonobstructive coronary artery disease based on CT angiography findings. A 12 month follow up study. J Cardiovasc Thorac Res 2019;11(4):318-321. doi: 10.15171/jcvtr.2019.52.
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