Submitted: 17 Jan 2019
Accepted: 24 Apr 2020
ePublished: 31 May 2020
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J Cardiovasc Thorac Res. 2020;12(2): 114-119.
doi: 10.34172/jcvtr.2020.19
PMID: 32626551
PMCID: PMC7321005
  Abstract View: 247
  PDF Download: 129

Original Article

Association of epicardial fat thickness assessed by echocardiography with the severity of coronary artery disease

Alireza Rostamzadeh 1 ORCID logo, Kamal Khademvatani 1* ORCID logo, Mir Hossein Seyed Mohammadzadeh 1, Shahrzad Ashori 2, Mojgan Hajahmadi Poorrafsanjani 1, Behzad Rahimi 1, Behshid Ghadrdoost 3 ORCID logo

1 Seyyed-al Shohada University Hospital, Urmia University of Medical Sciences, Urmia, Iran
2 Urmia University of Medical Sciences, Urmia, Iran
3 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Kamal Khademvatani, Email: khademvatan2002@yahoo.com


Introduction: Epicardial fat thickness (EFT) can reflect risk of cardiovascular disease particularly coronary artery disease (CAD). The aim of this study was to investigate the association of EFT assessed by echocardiography and presence as well as severity of CAD.

Methods: Two hundred and twenty consecutive patients who candidate for coronary angiography because of possible CAD were studied. EFT was evaluated in standard parasternal long axis (PlAX) and parasternal short axis (PSAX) view from 3 cardiac cycles at the end of systole and diastole. The severity of CAD was defined in two ways: (1) SYNTAX score, (2) number of vessels with significant lesion.

Results: PLAX (EFTS ) (EFT in systole) and PLAX (EFTd ) (EFT in diastole) were significantly higher in patients with CAD in comparison with patients without CAD (P = 0.046, P = 0.041 respectively). There was a significant correlation between PLAX (EFTS ) (P = 0.05), PLAX (EFTd ) (P = 0.04) and SYNTAX score. There was no statistically significant relationship between EFT and number of diseased vessel (P > 0.05). Multivariate analysis was done for adjusting the effects of confounding factors and it showed that EFT (OR: 10.53, P = 0.004) was significantly correlated severe CAD as assessed by the SYNTAX score.

Conclusion: EFT assessed by transthoracic echocardiography was higher significantly in patients with CAD than in normal patients. EFT as an easily available and cost-effective echocardiographic feature might be useful to predict complexity of CAD.

Keywords: Epicardial Fat Thickness, Coronary Artery Disease, SYNTAX Score, Echocardiography
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