Submitted: 29 Jul 2019
Revision: 01 Aug 2020
Accepted: 03 Aug 2020
ePublished: 05 Sep 2020
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J Cardiovasc Thorac Res. 2020;12(3): 209-213.
doi: 10.34172/jcvtr.2020.35
  Abstract View: 88
  PDF Download: 107

Original Article

Pregnancy outcome in women with mechanical prosthetic heart valvesat their first trimester of pregnancy treated with unfractionated heparin (UFH) or enoxaparin: A randomized clinical trial

Minoo Movahedi 1, Maryam Motamedi 1 ORCID logo, Amirreza Sajjadieh 2* ORCID logo, Parvin Bahrami 2 ORCID logo, Mahmood Saeedi 3, Milad Saeedi 4

1 Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Cardiac Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of General Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Amirreza Sajjadieh, Email: amirsajjadieh@yahoo.com


Introduction: Pregnancy increases the risks of thromboembolism for the mother and fetus in patients with mechanical heart valves. The results of some studies have indicated that low molecular weight heparin (LMWH), in comparison with unfractionated heparin (UFH), leads to a lower incidence rate of thrombocytopenia and a decrease in bleeding.
Methods: The present randomized clinical trial involved 31 pregnant women with mechanical heart valves at their first trimester (0-14 weeks) of pregnancy. To perform the study, the patients were divided into two groups, i.e. group A (LMWH group-16 patients) and group B (UFH group-15 patients). The birth weight, mode of delivery, and gestational age at birth as well as the maternal and fetal complications were compared between the two groups.
Results: The mean age of mothers in the UFH and LMWH groups was 32.67±9.11 and 31.50±5.81years, respectively (P value > 0.05). Although the rate of maternal and fetal complications was higher in the UFH group as compared with the LMWH group, the observed difference was not significant (P value > 0.05).
Conclusion: LMWH can be regarded as a safer therapy for both the mother and fetus due to its lower number of refill prescriptions and fewer changes in the blood level.
Keywords: Low Molecular Weight Heparin, Mechanical Heart Valves, Pregnancy, Unfractionated Heparin
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