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Submitted: 21 Oct 2019
Accepted: 14 Dec 2020
ePublished: 19 Jan 2021
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J Cardiovasc Thorac Res. 2021;13(1): 79-83.
doi: 10.34172/jcvtr.2021.06
  Abstract View: 90
  PDF Download: 31

Short Communication

Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study

Farzad Kakaei 1,2 ORCID logo, Saba Mirabolfathi 3, Negin Yavari 4, Mohammad Reza Ardalan 5, Mehrdad Mozafar 6, Sina Zarrintan 7* ORCID logo

1 Department of General Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 Section of Organ Transplantation, Tabriz University of Medical Sciences, Tabriz, Iran
3 Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
5 Division of Nephrology, Department of Internal Medicine, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
6 Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Sina Zarrintan, Email: s.zarrintan@yahoo.com

Abstract

Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis.

Methods: In this cross-sectional study, 60 consecutive patients with ESRD on HD with tunneled cuffed catheters were selected. Inherited thrombophilia factors (Anti-thrombin III, Protein C, Protein S, and Factor V Leiden) were measured and the patients were followed for 3 months to evaluate the incidence of catheter-related thrombosis. The association between these factors and catheter thrombosis was assessed.

Results: The mean age of patients was 60.30 ± 8.69 years. Forty-seven patients (78.30%) were female and thirteen patients (21.70%) were male. The most common cause of ESRD was diabetes mellitus (41.67%). The most catheter site was the right internal jugular vein (55%). There were 22 (36.67%) and 8 (13.33%) cases of thrombosis and mortality, respectively. The association between hereditary thrombophilia factors and catheter thrombosis was not statistically significant (P > 0.05).

Conclusion: In this small group of our patients, the frequency of hereditary thrombophilia was not significantly different between those with and without thrombosis of tunneled HD catheter.

Keywords: Thrombophilia, Hemodialysis, Thrombosis, Tunneled Hemodialysis Catheter
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