Submitted: 23 Jan 2020
Accepted: 18 Jul 2021
ePublished: 25 Aug 2021
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J Cardiovasc Thorac Res. 2021;13(3): 208-215.
doi: 10.34172/jcvtr.2021.39
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Original Article

A discrepancy between CT angiography and transesophageal echocardiographic measurements of the annular size affect long-term survival following trans-catheter aortic valve replacement

Siddarth Singh 1 ORCID logo, Piotr S. Rutkowski 2 ORCID logo, Alexey Dyachkov 3 ORCID logo, Vijay S. Iyer 4, Leili Pourafkari 5 ORCID logo, Nader D. Nader 2* ORCID logo

1 Department of Anesthesiology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
2 Department of Anesthesiology, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
3 Department of Anesthesiology, Geisinger Medical Center, Danville, PA, USA
4 Gates Vascular Institute, Interventional Cardiology, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
5 Catholic Health System, University at Buffalo Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY, USA
*Corresponding Author: Nader D. Nader, Email: nnader@buffalo.edu


Introduction: Accurate measurement of the aortic valve annulus is critical for proper valve sizing for the transcatheter aortic valve replacement (TAVR) procedure. While computed tomography angiography (CTA) is the widely-accepted standard, two-dimensional (2D) and three-dimensional(3D) transesophageal echocardiography (TEE) is commonly performed to measure the size of the aortic valve and to verify appropriate seating of prostheses.
Methods: Patients undergoing TAVR between 2013-2015 were examined. 2D- and 3D-TEEmeasurements were compared to CTA taken as standard. Patients were followed for at least one year. The presence and effect of discrepancy (defined as a difference of more than 10%) between CTA and TEE measurements on survival were examined.
Results: One hundred eighty-five patients (70 men) were included. 2D- and 3D-TEE measurements underestimated the annulus size by -1.49 and -1.32 mm, respectively. Discrepancies > 10% between TEE and CTA methods in estimating the aortic annulus size were associated with a decrease in post implant survival. The peak pressure gradient across the aortic prosthesis measured one year after the implant was higher in patients with an initial discrepancy between 3D-TEE and CTA measurements. In a multivariate cox-regression model, the discrepancy between CTA and 2D-TEE readings and the smaller size of the aortic annular area were the predictors of long-term survival.
Conclusion: Both 2D and 3D-TEE underestimate the aortic annulus measurements compared to CTA, with 2D-TEE being relatively more precise than 3D-TEE technology. The presence of a discrepancy between echocardiographic and CTA measurements of the aortic annulus is associated with a lower survival rate.
Keywords: Aortic Stenosis, Computed Tomographic, Angiography, Echocardiography, Trans-catheter Aortic Valve, Replacement

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