Submitted: 30 May 2020
Accepted: 02 Nov 2020
ePublished: 23 Dec 2020
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J Cardiovasc Thorac Res. 2021;13(1): 15-22.
doi: 10.34172/jcvtr.2020.59
  Abstract View: 128
  PDF Download: 49

Review Article

Coagulopathy: Another side effect of coronavirus infection

Fatemeh Sadoughi 1, Parisa Maleki Dana 1, Jamal Hallajzadeh 2* ORCID logo, Zatollah Asemi 1* ORCID logo, Mohammad Ali Mansournia 3, Bahman Yousefi 4

1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
2 Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran
3 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Authors: Zatollah Asemi, Email: asemi_r@yahoo.com


Recently, coronavirus disease 2019 (COVID-19) has been considered as a major health problem around the globe. This severe acute respiratory syndrome has a bunch of features, such as high transmission rate, which are adding to its importance. Overcoming this disease relies on a complete understanding of the viral structure, receptors, at-risk cells or tissues, and pathogenesis. Currently, researches have shown that besides the lack of a proper anti-viral therapeutic method, complications provided by this virus are also standing in the way of decreasing its mortality rate. One of these complications is believed to be a hematologic manifestation. Commonly, three kinds of coagulopathies are detected in COVID-19 patients: disseminated intravascular coagulation (DIC), pulmonary embolism (PE), and deep vein thrombosis (DVT). In this paper, we have reviewed the relation between these conditions and coronavirus-related diseases pathogenesis, severity, and mortality rate.

Keywords: SARS, COVID-19, CoV, Heparin, DIC, PIC, VTE
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