Submitted: 06 Jun 2020
Revision: 04 Sep 2020
Accepted: 20 Oct 2020
ePublished: 28 Nov 2020
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J Cardiovasc Thorac Res. 2020;12(4): 303-306.
doi: 10.34172/jcvtr.2020.49
  Abstract View: 53
  PDF Download: 45

Original Article

Association of rs4618210A>G variant in PLCL2 gene with myocardial infarction: A case-control study in Iran

Najmeh Ramezanpour ORCID logo, Mahboobeh Nasiri* ORCID logo, Omid Reza Akbarpour


Introduction: Myocardial infarction (MI) is the leading cause of death all over the world. The pivotal roles of Phospholipase C like 2 gene (PLCL2) in calcium homeostasis and immune responses make this gene as a potential candidate for its role in MI pathogenesis. The present study was undertaken to investigate whether rs4618210A>G polymorphism in PLCL2 gene contribute to MI etiology.
Methods: A hospital-based case-control study with 600 subjects, including 300 MI patients and 300controls, was conducted. Genotyping of PLCL2 rs4618210 polymorphism was performed using amplification refractory mutation system-polymerase chain reaction (ARMS PCR) method. Data were analyzed using logistic regression analysis.
Results: No significant association was found between the PLCL2 rs4618210 alleles and MI risk.However, a significantly increased risk of MI was observed among carriers of the AG genotype (OR= 1.91; 95% CI = 1.24 - 2.93; P = 0.003) compared with AA homozygote. In a dominant mode of inheritance for G allele (GG + AG vs. AA), the frequency of the carriers of at least one G allele was higher in cases compared to controls (OR= 1.56; 95% CI: 1.03 – 2.36; P = 0.037).
Conclusion: Our study provided further evidence that PLCL2 gene polymorphism may serve as a prognostic marker for MI.
Keywords: Polymorphism, PLCL2, Myocardial Infraction
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