Olapeju Daniyan
1* 
, Obumneme Ezeanosike
1,2, Dorathy Obu
1, Fortune Ujunwa
1,31 Department of Paediatrics, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria
2 Department of Paediatrics, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
3 Department of Paediatrics, College of Medicine University of Nigeria, Enugu Campus, Enugu, Nigeria
Abstract
We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. Therefore, in situations where inhaled nitric oxide is not available it may be used as an alternative therapy in PPHN. Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics.