Mahdiyeh Khabbaz Koche Ghazi
1 
, Samad Ghaffari
2, Mohammad Naemi
1, Rezvaniyeh Salehi
2, Mohammadreza Taban Sadeghi
2, Meisam Barati
3, Alireza Namazi Shabestari
4, Behnam Kafil
1, Naimeh Mesri Alamdari
5,6, Hamid Soleimanzadeh
7, Ali Tarighat-Esfanjani
1* , Neda Roshanravan
2* 1 Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6 Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
7 Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
Abstract
Introduction: Atherosclerosis and related cardiovascular diseases (CVDs) are the major causes of mortality worldwide. The available reports regarding the effects of selenium (Se) supplementation in the realm of atherosclerosis have been equivocal. The present investigation is aimed to assess the effects of sodium selenite and Se-enriched yeast supplementation on metabolic parameters among atherosclerotic patients.
Methods: In this double-blind placebo-controlled randomized clinical trial, 60 patients diagnosed with atherosclerosis were randomly allocated into either 200 μg/day selenite, yeast, or placebo groups for eight consecutive weeks. Serum levels of lipid profile and glycemic indices were measured at the baseline and end of the intervention.
Results: There were no significant within-or between-group changes in levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), fasting blood sugar, insulin, and homeostatic model assessment for IR throughout the study (P≥0.05). Only the low density lipoprotein cholesterol (LDL-c) levels were significantly lower in the yeast group in comparison with the placebo group (P= 0.015).
Conclusion: The administration of Se-enriched yeast is significantly effective in decreasing LDL-c levels in patients with atherosclerosis. Additional clinical trial studies investigating the effect of Se administration on glucose homeostasis parameters and lipid profiles in atherosclerotic patients are suggested for a more definitive conclusion.