Logo-jcvtr
Submitted: 07 Jan 2022
Revision: 25 May 2022
Accepted: 16 Aug 2022
ePublished: 30 Aug 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Cardiovasc Thorac Res. 2022;14(3): 159-165.
doi: 10.34172/jcvtr.2022.28
PMID: 36398053
PMCID: PMC9617055
Scopus ID: 85140404197
  Abstract View: 321
  PDF Download: 242
  Full Text View: 31

Original Article

Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women

Behnam Heidari 1 ORCID logo, Mohammad Reza Zolfaghari 1* ORCID logo, Kamal Khademvatani 2, Amir Fattahi 3* ORCID logo, Reza Zarezadeh 4 ORCID logo

1 Department of Physical Education, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2 Cardiology Department, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3 Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Authors: Corresponding Author: Mohammad Reza Zolfaghari Email: , Email: zolfaghari60@gmail.com; Corresponding Authors: Amir Fattahi, Email: , Email: fattahia@tbzmed.ac.ir

Abstract

Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and bradykinin (BK) and their association with cardiac hypertrophy.

Methods: 22 non-athlete and 22 athlete women were exposed to acute (Bruce test) and chronic (12-week swimming training) exercises. 2D echocardiography was used to evaluate morphological and functional features of the heart. Plasma concentrations of TK and BK were quantified by ELISA.

Results: Athletes had significantly higher values of left ventricle end-diastolic diameter index (LVEDDI) and left ventricle mass index (LVMI) than non-athletes. Exercise intervention affected echocardiographic features in neither of the study groups. Chronic exercise training notably increased plasma levels of TK and BK, which increase was more pronounced in the athletes. Plasma TK negatively correlated with LVEDDI (r=−0.64, P=0.036 and r=−0.58, P=0.027) and LVMI (r=−0.51, P=0.032 and r=−0.63, P=0.028) in the non-athlete and athlete groups. In opposition, there was a positive correlation between plasma TK and left ventricle ejection fraction in non-athletes (r=0.39, P=0.049) and athletes (r=0.53, P=0.019).

Conclusion: The upregulation of the tissue kallikrein-kinin system may be a protective mechanism against excessive cardiac hypertrophy induced by chronic exercise training.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 322

Your browser does not support the canvas element.


PDF Download: 242

Your browser does not support the canvas element.


Full Text View: 31

Your browser does not support the canvas element.