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Submitted: 20 Aug 2022
Revision: 25 May 2023
Accepted: 25 May 2023
ePublished: 29 Jun 2023
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J Cardiovasc Thorac Res. 2023;15(2): 98-105.
doi: 10.34172/jcvtr.2023.31623
PMID: 37654815
PMCID: PMC10466463
  Abstract View: 715
  PDF Download: 335
  Full Text View: 191

Original Article

Comparative study of the effect of two different doses of intravenous labetalol on the cardiovascular response to endotracheal extubation

Hamidreza Shetabi 1* ORCID logo, Behzad Nazemroaya 1, Hosein Mahjobipoor 1, Sanaz Majidi 2 ORCID logo

1 Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Hamidreza Shetabi, Email: hamidshetabi@med.mui.ac.ir

Abstract

Introduction: Providing a stable hemodynamic in extubation is important. We aimed to compare the effect of two different doses of intravenous labetalol on the cardiovascular response to endotracheal extubation.

Methods: This double-blind randomized trial was performed in 2019-2020 in Isfahan on 72 patients under general anesthesia. Patients using Random Allocation software were divided into three groups and received 0.1 mg/ kg or 0.2 mg/kg labetalol and normal saline intravenously 10 min before extubation. Hemodynamic variables including heart rate (HR), Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and peripheral blood oxygen saturation(SPO2) was measured for each patient before induction of anesthesia and 1, 3, 5 and 10 minutes after extubation.

Results: SBP changes were significantly different between the three groups at 1, 3, 5 minutes after extubation (P=0.036, P=0.009, P=0.005 respectively) unlike the other two groups, patients who received 0.2 mg/kg labetalol did not have an increase in DBP after extubation (P>0.05). DBP was significantly different between the three groups one minute after extubation (P=0.03). At minutes 1 and 3 following extubation, there was a significant difference in the MAP between the three groups. (P=0.029 and P=0.012 respectively). There was no significant difference between the three groups regarding heart rate (P>0.05).

Conclusion: Tracheal extubation is usually associated with an increase in hemodynamic variables. Both doses of labetalol attenuate the hemodynamic response accompanying tracheal extubation. But labetalol 0.2 mg/kg in reducing hemodynamic response to extubation acted more effectively than labetalol 0.1mg/kg.

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Full Text View: 191

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