Submitted: 09 Jun 2023
Revision: 02 Sep 2023
Accepted: 27 Nov 2023
ePublished: 30 Dec 2023
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J Cardiovasc Thorac Res. 2023;15(4): 262-268.
doi: 10.34172/jcvtr.2023.32880
PMID: 38357562
PMCID: PMC10862030
  Abstract View: 361
  PDF Download: 313

Case Series

Assessment of ventricular function after total cavo-pulmonary derivation in adult patients: Interest of global longitudinal strain

Kaouther Hakim 1 ORCID logo, Nouha Mekki 1* ORCID logo, Rihab Benothmen 1, Mokbli Malek 2, Jarray Abdelkader 2, Msaad Hela 1, Habiba Mizouni 2, Ouarda Fatma 1

1 Pediatric Cardiology Department, La Rabta University Hospital of Tunis, Tunisia
2 Radiology Department, La Rabta University Hospital of Tunis, Tunisia
*Corresponding Author: Mekki Nouha, Email: nouhamekki2373@gmail.com


Ventricular dysfunction is the most frequent complication in adult patients post-Fontan completion. Through this work, we aim to evaluate ventricular systolic function by conventional echographic parameters and by global longitudinal strain (GLS) to determine the prediction of early ventricular systolic dysfunction. This is a prospective monocentric study enrolling 15 clinically stable adult Fontan patients with preserved ejection fraction (EF). Myocardial deformation study by GLS with speckle tracking technique in addition to a standard Doppler transthoracic echocardiography (TTE) was performed. Cardiac magnetic resonance imaging (CMR) was also performed. A comparison of echocardiographic and CMR parameters was made. In comparison to CMR-derived EF, we found a significant correlation with GLS and TTE-derived EF (P=0.003 and 0.014). We divided our population into two groups based on the cut-off value of 50% of CMR derived EF. Comparison of GLS in both groups showed a significant correlation (P=0.003). A cut-off value of -13.3% showed sensitivity of 67% and specificity of 100%. GLS has a moderate diagnostic value for systolic myocardial dysfunction in the population of adult patients with Fontan circulation.
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