Ambili Parekumbel Venu
1* 
, Rajamanickam Rajkumar
2* , Divakaran Dinesh Roy
3* , Sreelal Thekkumkara Prabhakaran
4, Kanagasabapathy Shankar
2, Vidhyadharan Jayapal
5, Sureka Varalakshmi
2, Sreeja Sreenivasan
11 Research Scholar, Meenakshi Academy of Higher Education and Research (MAHER-Deemed to be University), West K.K Nagar, Chennai, Tamil Nadu, India
2 Meenakshi Medical College Hospital & Research Institute, Meenakshi Academy of Higher Education and Research (MAHER-Deemed to be University), Kanchipuram, Tamil Nadu, India
3 Genetika Centre for Advanced Genetic Studies, Thiruvananthapuram, Kerala, India
4 Dr Moopen’s Medical College, Wayanad, Kerala, India
5 Hridayalaya Heart Foundation, Thiruvananthapuram, Kerala, India
Abstract
The research aimed to evaluate the association between heart-type fatty acid binding protein (H-FABP) and cardiovascular events. We systematically reviewed research that has been conducted to assess this relationship, aiming to determine how useful H-FABP could be as a biomarker for cardiovascular diseases, especially in the initial phases of acute myocardial infarction (AMI) and acute coronary syndrome (ACS). Our goal was to validate its diagnostic accuracy and clinical relevance. We systematically searched through PubMed, Web of Science, and Google Scholar databases to find pertinent publications related to cardiovascular diseases and H-FABP, using various permutations, abbreviations, and language variations of MeSH keywords. The final analysis included 12 studies in total. The final study comprised twelve studies, and it was concluded that H-FABP demonstrated high sensitivity (64.3-91.5) and specificity (73-100) for diagnosing Acute Myocardial Infarction (AMI) and Acute Coronary Syndrome (ACS), especially within the first hours of symptom onset. H-FABP demonstrates potential in enhancing the overall diagnostic accuracy during the initial hours following the manifestation of symptoms. However, the existing data do not provide sufficient evidence to recommend the regular utilization of H-FABP as a preliminary risk assessment approach in individuals who present with suspected cardiac events. Additional investigations, with well-defined prospective cohorts, are needed to validate the results observed.