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Submitted: 16 May 2024
Accepted: 27 Jul 2024
ePublished: 20 Sep 2024
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J Cardiovasc Thorac Res. 2024;16(3): 164-170.
doi: 10.34172/jcvtr.33184
  Abstract View: 62
  PDF Download: 56

Original Article

Impact of prior aspirin use on left ventricular function in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: An echocardiographic evaluation

Yosef Yosefzadeh 1 ORCID logo, Mahdokht Rezaei 2* ORCID logo, Abbas Allami 3* ORCID logo, Ali Hosseinsabet 4 ORCID logo

1 Department of Cardiology, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2 Department of Cardiology, Faculty of Medicine, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
3 Department of Infectious Diseases, Faculty of Medicine, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
4 Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Authors: Mahdokht Rezaei, Email: rezaiemahdokht@yahoo.com; Abbas Allami, Email: allami9@yahoo.com

Abstract

Introduction: Previous studies have investigated the potential influence of prior aspirin use on cardiac function in patients with ST-elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (PPCI). However, the results from these studies have been conflicting. This study aimed to investigate whether prior aspirin use affects left ventricular (LV) function in these patients using echocardiography.

Methods: The study included 260 consecutive STEMI patients, who were divided into two groups based on the presence or absence of prior aspirin use. Echocardiographic parameters, such as maximal left atrial (LA) size, LV ejection fraction (LVEF), early diastolic velocity (e’), E/A ratio, and E/e’ ratio, were assessed within 72 hours of admission.

Results: Aspirin users had an older age compared to non-users, as well as lower body mass index and renal function. They also had a greater history of hypertension and were more likely to be taking statins, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and calcium channel blockers. There were no significant differences in LVEF, maximal LA size, E/A ratio, E/e’ ratio, and deceleration time between aspirin users and non-users. e’ wave was marginally lower in aspirin users (P=0.054). After controlling for confounding variables, the previous use of aspirin did not show a significant impact.

Conclusion: Prior aspirin use in STEMI patients does not have a significant impact on LV echocardiographic parameters. Our conclusions remained consistent even after adjusting for potential confounders.

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