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J Cardiovasc Thorac Res. 2015;7(2): 43-48. doi: 10.15171/jcvtr.2015.10
PMID: 26191390        PMCID: PMC4492176

Review Article

The Impact of High Versus Low Sedation Dosing Strategy on Cognitive Dysfunction in Survivors of Intensive Care Units: A Systematic Review and Meta-Analysis

Jahan Porhomayon 1, Philippe A Joude, Ghazaleh Adlparvar 3, Ali A El-Solh 2, Nader D Nader 4 *

Cited by CrossRef: 20


1- Terada Y, Inoue S, Konda M, Egawa J, Ueda J, Kirita T, Kawaguchi M. Effects of deep sedation under mechanical ventilation on cognitive outcome in patients undergoing surgery for oral and maxillofacial cancer and microvascular reconstruction. Medicina Intensiva (English Edition). 2019;43(1):3 [Crossref]
2- Ortlepp J, Luethje F, Walz R. Analgesie in der Intensivmedizin. Med Klin Intensivmed Notfmed. 2016;111(1):6 [Crossref]
3- Leigh V, Stern C, Elliott R, Tufanaru C. Effectiveness and harms of pharmacological interventions for the treatment of delirium in adults in intensive care units after cardiac surgery. JBI Database of Systematic Reviews and Implementation Reports. 2019;17(10):2020 [Crossref]
4- Wilcox M, Girard T, Hough C. Delirium and long term cognition in critically ill patients. BMJ. 2021;:n1007 [Crossref]
5- Sutton‐Smith L. A quality improvement project to improve the identification and management of delirium. Nurs Crit Care. 2021;26(3):183 [Crossref]
6- Foster J, Burry L, Thabane L, Choong K, Menon K, Duffett M, Cheung A, Guenette M, Chimunda T, Rose L. Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol. Syst Rev. 2016;5(1) [Crossref]
7- Brown S, Beesley S, Stubben C, Wilson E, Presson A, Grissom C, Maguire C, Rondina M, Hopkins R. Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. J Intensive Care Med. 2021;36(3):262 [Crossref]
8- Nedergaard H, Jensen H, Stylsvig M, Lauridsen J, Toft P. Non-sedation versus sedation with a daily wake-up trial in critically ill patients recieving mechanical ventilation - effects on long-term cognitive function: Study protocol for a randomized controlled trial, a substudy of the NONSEDA trial. Trials. 2016;17(1) [Crossref]
9- Umholtz M, Cilnyk J, Wang C, Porhomayon J, Pourafkari L, Nader N. Postanesthesia emergence in patients with post-traumatic stress disorder. Journal of Clinical Anesthesia. 2016;34:3 [Crossref]
10- Nunes S, Forsberg S, Blomqvist H, Berggren L, Sörberg M, Sarapohja T, Wickerts C. Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit. Clin Drug Investig. 2018;38(6):535 [Crossref]
11- Reznik M, Berger K, Claassen J. Comparison of Intravenous Anesthetic Agents for the Treatment of Refractory Status Epilepticus. JCM. 2016;5(5):54 [Crossref]
12- Neme D, Aweke Z, Micho H, Mola S, Jemal B, Regasa T.

Evidence-Based Guideline for Adult Sedation, Pain Assessment, and Analgesia in a Low Resource Setting Intensive Care Unit: Review Article

. IJGM. 2020;Volume 13:1445 [Crossref]
13- Acevedo-Nuevo M, González-Gil M, Romera-Ortega M, Latorre-Marco I, Rodríguez-Huerta M. The early diagnosis and management of mixed delirium in a patient placed on ECMO and with difficult sedation: A case report. Intensive and Critical Care Nursing. 2018;44:110 [Crossref]
14- Terada Y, Inoue S, Konda M, Egawa J, Ueda J, Kirita T, Kawaguchi M. Effects of deep sedation under mechanical ventilation on cognitive outcome in patients undergoing surgery for oral and maxillofacial cancer and microvascular reconstruction. Medicina Intensiva. 2019;43(1):3 [Crossref]
15- Leigh V, Tufanaru C, Elliott R. Effectiveness and harms of pharmacological interventions in the treatment of delirium in adults in intensive care units post cardiac surgery. JBI Database of Systematic Reviews and Implementation Reports. 2018;16(5):1117 [Crossref]
16- Ohtake P, Lee A, Scott J, Hinman R, Ali N, Hinkson C, Needham D, Shutter L, Smith-Gabai H, Spires M, Thiele A, Wiencek C, Smith J. Physical Impairments Associated With Post–Intensive Care Syndrome: Systematic Review Based on the World Health Organization's International Classification of Functioning, Disability and Health Framework. 2018;98(8):631 [Crossref]
17- Mikkelsen M, Still M, Anderson B, Bienvenu O, Brodsky M, Brummel N, Butcher B, Clay A, Felt H, Ferrante L, Haines K, Harhay M, Hope A, Hopkins R, Hosey M, Hough C, Jackson J, Johnson A, Khan B, Lone N, MacTavish P, McPeake J, Montgomery-Yates A, Needham D, Netzer G, Schorr C, Skidmore B, Stollings J, Umberger R, Andrews A, Iwashyna T, Sevin C. Society of Critical Care Medicine’s International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness. 2020;48(11):1670 [Crossref]
18- Radnis C, Qiu S, Jhaveri M, Da Silva I, Szewka A, Koffman L. Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia. Journal of the Neurological Sciences. 2020;418:117119 [Crossref]
19- Trevick S, Kim M, Naidech A. Communication, Leadership, and Decision-Making in the Neuro-ICU. Curr Neurol Neurosci Rep. 2016;16(11) [Crossref]
20- Carraway J, Carraway M, Truelove C. Nursing implementation of a validated agitation and sedation scale: An evaluation of its outcomes on ventilator days and ICU length of stay. Applied Nursing Research. 2021;57:151372 [Crossref]