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J Cardiovasc Thorac Res. 2015;7(3): 81-86. doi: 10.15171/jcvtr.2015.19
PMID: 26430494        PMCID: PMC4586603

Original Article

The Effect of Lipopolysaccharide on Ischemic-Reperfusion Injury of Heart: A Double Hit Model of Myocardial Ischemia and Endotoxemia

Nader D. Nader 1 * , Mehrdad Asgeri 2, Sina Davari-Farid 1, Leili Pourafkari 3, Faraz Ahmadpour 4, Jahan Porhomayon 1, Hassan Javadzadeghan 1, Sohrab Negargar 3, Paul R. Knight III 1

Cited by CrossRef: 7


1- Kim J, Lee D, Kim J, Jung S, Ham S, Yang W, Kwon B. Anti-inflammatory Effects of Ojeok-san in LPS-induced Inflammatory Rat Model. J Korean Med. 2021;42(2):21 [Crossref]
2- Borshchev Y, Minasian S, Burovenko I, Borshchev V, Protsak E, Semenova N, Borshcheva O, Galagudza M, Bader M. Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis. PLoS ONE. 2019;14(11):e0225185 [Crossref]
3- Nguyen M, Gautier T, Masson D, Bouhemad B, Guinot P. Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options. JCM. 2023;12(7):2579 [Crossref]
4- Honda T, Inagawa H. Utility of In Vitro Cellular Models of Low-Dose Lipopolysaccharide in Elucidating the Mechanisms of Anti-Inflammatory and Wound-Healing-Promoting Effects of Lipopolysaccharide Administration In Vivo. IJMS. 2023;24(18):14387 [Crossref]
5- Mao C, Zhang T, Li D, Zhou E, Fan Y, He Q, Wang C, Zhang J. Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway. WJSC. 2022;14(2):183 [Crossref]
6- Ghaffari S, Pourafkari L, Manzouri S, Nader N. Effect of remote ischemic postconditioning during thrombolysis in STEMI. Herz. 2018;43(2):161 [Crossref]
7- Okuhara Y, Yokoe S, Iwasaku T, Eguchi A, Nishimura K, Li W, Oboshi M, Naito Y, Mano T, Asahi M, Okamura H, Masuyama T, Hirotani S. Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity. International Journal of Cardiology. 2017;243:396 [Crossref]
8- Wu T, Jiang N, Ji Z, Shi G. The IRE1 signaling pathway is involved in the protective effect of low-dose LPS on myocardial ischemia-reperfusion injury. Life Sciences. 2019;231:116569 [Crossref]