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J Cardiovasc Thorac Res. 2015;7(3): 81-86. doi: 10.15171/jcvtr.2015.19
PMID: 26430494        PMCID: PMC4586603

Original Article

The Effect of Lipopolysaccharide on Ischemic-Reperfusion Injury of Heart: A Double Hit Model of Myocardial Ischemia and Endotoxemia

Nader D. Nader 1 * , Mehrdad Asgeri 2, Sina Davari-Farid 1, Leili Pourafkari 3, Faraz Ahmadpour 4, Jahan Porhomayon 1, Hassan Javadzadeghan 1, Sohrab Negargar 3, Paul R. Knight III 1

Cited by CrossRef: 7

1- Kim J, Lee D, Kim J, Jung S, Ham S, Yang W, Kwon B. Anti-inflammatory Effects of Ojeok-san in LPS-induced Inflammatory Rat Model. J Korean Med. 2021;42(2):21 [Crossref]
2- Borshchev Y, Minasian S, Burovenko I, Borshchev V, Protsak E, Semenova N, Borshcheva O, Galagudza M, Bader M. Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis. PLoS ONE. 2019;14(11):e0225185 [Crossref]
3- Nguyen M, Gautier T, Masson D, Bouhemad B, Guinot P. Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options. JCM. 2023;12(7):2579 [Crossref]
4- Honda T, Inagawa H. Utility of In Vitro Cellular Models of Low-Dose Lipopolysaccharide in Elucidating the Mechanisms of Anti-Inflammatory and Wound-Healing-Promoting Effects of Lipopolysaccharide Administration In Vivo. IJMS. 2023;24(18):14387 [Crossref]
5- Mao C, Zhang T, Li D, Zhou E, Fan Y, He Q, Wang C, Zhang J. Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway. WJSC. 2022;14(2):183 [Crossref]
6- Habimana R, Seong J, Jo Y, Kim R, Kim H, Choi K, Kayumov M, Obiweluozor F, Kim W, Cho H, Kim D, Na K, Jeong I. Endotoxin Pretreatment Mitigates Myocardial Ischemia-Reperfusion Injury Through Preservation of Mitochondrial Respiration: A Combined Assessment of In Vivo, Ex Vivo, and In Vitro Data. IJMS. 2025;26(22):11162 [Crossref]
7- Ghaffari S, Pourafkari L, Manzouri S, Nader N. Effect of remote ischemic postconditioning during thrombolysis in STEMI. Herz. 2018;43(2):161 [Crossref]
8- Okuhara Y, Yokoe S, Iwasaku T, Eguchi A, Nishimura K, Li W, Oboshi M, Naito Y, Mano T, Asahi M, Okamura H, Masuyama T, Hirotani S. Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity. International Journal of Cardiology. 2017;243:396 [Crossref]
9- Wu T, Jiang N, Ji Z, Shi G. The IRE1 signaling pathway is involved in the protective effect of low-dose LPS on myocardial ischemia-reperfusion injury. Life Sciences. 2019;231:116569 [Crossref]