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J Cardiovasc Thorac Res. 2017;9(4): 200-208. doi: 10.15171/jcvtr.2017.35
PMID: 29391933        PMCID: PMC5787332

Original Article

Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease

Nasim Abedimanesh 1, S. Zahra Bathaie 2 * , Saeed Abedimanesh 2, Behrooz Motlagh 3, Ahmad Separham 4, Alireza Ostadrahimi 1 *

Cited by CrossRef: 35


1- Allkanjari O, Annetta A, Di Sotto A, Vitalone A. Safety of herbal dietary supplements used for weight loss: sales data and phytovigilance awareness. Nutrire. 2023;48(2) [Crossref]
2- Lu L, Wu D, Wang K, Tang J, Chen G. Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide. BioMed Research International. 2020;2020:1 [Crossref]
3- Rahimi G, Shams S, Aslani M. Effects of crocin supplementation on inflammatory markers, lipid profiles, insulin and cardioprotective indices in women with PCOS: A randomized, double‐blind, placebo‐controlled trial. Phytotherapy Research. 2022;36(6):2605 [Crossref]
4- Tajaddini A, Roshanravan N, Mobasseri M, Haleem Al‐qaim Z, Hadi A, Aeinehchi A, Sefid‐Mooye Azar P, Ostadrahimi A. The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type‐2 diabetes mellitus: A randomized placebo‐controlled trial. Phytotherapy Research. 2023;37(2):388 [Crossref]
5- Yan X, Zhao S, Feng X, Li X, Zhou Q, Chen Q. Effects of Crocus sativus on glycemic control and cardiometabolic parameters among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab (Lond). 2024;21(1) [Crossref]
6- Abedimanesh S, Bathaie S, Ostadrahimi A, Asghari Jafarabadi M, Taban Sadeghi M. The effect of crocetin supplementation on markers of atherogenic risk in patients with coronary artery disease: a pilot, randomized, double-blind, placebo-controlled clinical trial. Food Funct. 2019;10(11):7461 [Crossref]
7- Pages-García C, De Almagro M, Ruiz-Moreno J, De Castellar R, Xiong J. Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild‐to‐Moderate Anxiety During the COVID‐19 Lockdown. Depression and Anxiety. 2024;2024(1) [Crossref]
8- Khalaf H, El-Mansy A. The possible alleviating effect of saffron on chlorpyrifos experimentally induced cardiotoxicity: Histological, immunohistochemical and biochemical study. Acta Histochemica. 2019;121(4):472 [Crossref]
9- Abedimanesh N, Motlagh B, Abedimanesh S, Bathaie S, Separham A, Ostadrahimi A. Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF‐κB, and MCP‐1 in patients with coronary artery disease: A randomized placebo‐controlled clinical trial. Phytotherapy Research. 2020;34(5):1114 [Crossref]
10- Sohaei S, Hadi A, Karimi E, Arab A. Saffron supplementation effects on glycemic indices: a systematic review and meta-analysis of randomized controlled clinical trials. International Journal of Food Properties. 2020;23(1):1386 [Crossref]
11- Salek R, Dehghani M, Mohajeri S, Talaei A, Fanipakdel A, Javadinia S. Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Phytotherapy Research. 2021;35(9):5143 [Crossref]
12- Rahaman A, Kumari A, Farooq M, Zeng X, Hassan S, Khalifa I, Aadil R, Jahangir Chughtai M, Khaliq A, Ahmad N, Wajid M. Novel Extraction Techniques: An Effective Way to Retrieve the Bioactive Compounds from Saffron (Crocus Sativus). Food Reviews International. 2023;39(5):2655 [Crossref]
13- Hasani M, Malekahmadi M, Rezamand G, Estêvão M, Pizarro A, Heydari H, Hoong W, Arafah O, Barakeh A, Rahman A, Alrashidi M, Abu-Zaid A. Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021;15(6):102311 [Crossref]
14- Prameswari A, Kalanjati V, Yuliawati T, Yuliawati A, Miftahussurur M. Cardioprotective of Saffron (Crocus sativus L.) treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Digital Chinese Medicine. 2023;6(4):381 [Crossref]
15- Rahmani J, Manzari N, Thompson J, Clark C, Villanueva G, Varkaneh H, Mirmiran P. The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials. Phytotherapy Research. 2019;33(9):2244 [Crossref]
16- Rahmani J, Bazmi E, Clark C, Hashemi Nazari S. The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials. Complementary Therapies in Medicine. 2020;49:102298 [Crossref]
17- Tajaddini A, Roshanravan N, Mobasseri M, Aeinehchi A, Sefid‐Mooye Azar P, Hadi A, Ostadrahimi A. Saffron improves life and sleep quality, glycaemic status, lipid profile and liver function in diabetic patients: A double‐blind, placebo‐controlled, randomised clinical trial. Int J Clin Pract. 2021;75(8) [Crossref]
18- Singletary K. Saffron. Nutr Today. 2020;55(6):294 [Crossref]
19- Mousavi S, Mokhtari P, Asbaghi O, Rigi S, Persad E, Jayedi A, Rezvani H, Mahamat-Saleh Y, Sadeghi O. Does saffron supplementation have favorable effects on liver function indicators? A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition. 2022;62(23):6315 [Crossref]
20- Mafi A, Mokhtari Z, Hosseini E, Alimohammadi M, Aarabi M, Askari G. Effect of Saffron (Crocus sativus) Supplementation on Oxidative Stress, Inflammatory Indices, and Renal and Liver Function Parameters in Patients With Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Clinical Trials. 2024; [Crossref]
21- Zamani M, Zarei M, Nikbaf-Shandiz M, Gholami F, Hosseini A, Nadery M, Shiraseb F, Asbaghi O. The effects of saffron supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Front Nutr. 2022;9 [Crossref]
22- Kadoglou N, Christodoulou E, Kostomitsopoulos N, Valsami G. The cardiovascular‐protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature. Phytotherapy Research. 2021;35(12):6735 [Crossref]
23- Tahmasbi F, Araj‐Khodaei M, Mahmoodpoor A, Sanaie S. Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2022;36(9):3394 [Crossref]
24- Si W, Xiong L, Zhou H, Wu H, Liu Z, Liu G, Liu Y, Shen A, Liang X. Comprehensive characterization of ingredients in Crocus sativus L. from different origins based on the combination of targeted and nontargeted strategies. Food Chemistry. 2022;397:133777 [Crossref]
25- Krishnaswamy V, Alugoju P, Periyasamy L. Effect of short-term oral supplementation of crocin on age-related oxidative stress, cholinergic, and mitochondrial dysfunction in rat cerebral cortex. Life Sciences. 2020;263:118545 [Crossref]
26- Mohammadi S, Naseri M, Faridi N, Zareie P, Zare L, Mirnajafi-Zadeh J, Bathaie S. Saffron carotenoids reversed the UCMS-induced depression and anxiety in rats: Behavioral and biochemical parameters, and hippocampal BDNF/ERK/CREB and NR2B signaling markers. Phytomedicine. 2023;119:154989 [Crossref]
27- Mykhailenko O, Petrikaite V, Korinek M, Chang F, El-Shazly M, Yen C, Bezruk I, Chen B, Hsieh C, Lytkin D, Ivanauskas L, Georgiyants V, Hwang T. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts. Molecules. 2021;27(1):10 [Crossref]
28- Kianmehr M, Mahdizadeh F, Khazdair M. The effects of Crocus sativus L. (Saffron) and its ingredients on dietary intakes in cardiovascular disease in Iranian population: A systematic review and meta-analysis. Front Nutr. 2022;9 [Crossref]
29- Shokri-Mashhadi N, Baechle C, Schiemann T, Schaefer E, Barbaresko J, Schlesinger S. Effects of carotenoid supplementation on glycemic control: a systematic review and meta-analysis of randomized clinical trials. Eur J Clin Nutr. 2024; [Crossref]
30- Drewnowski A. A novel Nutrient Rich Food (NRFa11.3) score uses flavonoids and carotenoids to identify antioxidant-rich spices, herbs, vegetables, and fruit. Front Nutr. 2024;11 [Crossref]
31- Asbaghi O, Soltani S, Norouzi N, Milajerdi A, Choobkar S, Asemi Z. The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 2019;47:102158 [Crossref]
32- Ahmadikhatir S, Ostadrahimi A, Safaiyan A, Ahmadikhatir S, Farrin N. Saffron (Crocus sativus L.) supplements improve quality of life and appetite in atherosclerosis patients. 2022;27(1):30 [Crossref]
33- Pourmasoumi M, Hadi A, Najafgholizadeh A, Kafeshani M, Sahebkar A. Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis. Pharmacological Research. 2019;139:348 [Crossref]
34- naserizadeh S, Taherifard M, Shekari M, Mesrkanlou H, Asbaghi O, Nazarian B, Khosroshahi M, Heydarpour F. The effect of crocin supplementation on lipid concentrations and fasting blood glucose: A systematic review and meta-analysis and meta-regression of randomized controlled trials. Complementary Therapies in Medicine. 2020;52:102500 [Crossref]
35- Roshanravan N, Ghaffari S. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytotherapy Research. 2022;36(1):98 [Crossref]
36- Mir R, Tyagi A, Hussain S, Almalki M, Zeyad M, Deshmukh R, Ali S. Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities. Plants. 2024;13(11):1467 [Crossref]
37- Ramli F, Abu Bakar Sajak A, Abas F, Mat Daud Z, Azlan A. Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats. BioMed Research International. 2020;2020:1 [Crossref]
38- Giannoulaki P, Kotzakioulafi E, Chourdakis M, Hatzitolios A, Didangelos T. Impact of Crocus sativus L. on Metabolic Profile in Patients with Diabetes Mellitus or Metabolic Syndrome: A Systematic Review. Nutrients. 2020;12(5):1424 [Crossref]
39- Algandaby M. Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK. Saudi Journal of Biological Sciences. 2020;27(5):1310 [Crossref]
40- Dastkhosh A, Behrouz V, Sohrab G, Nikpayam O, Sedaghat M, Ebrahimof S. What are the effects of crocin supplementation on lipid profile and oxidative stress in patients with type 2 diabetes? A randomized clinical trial. Journal of Functional Foods. 2024;121:106396 [Crossref]