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J Cardiovasc Thorac Res. 2015;7(4): 141-148. doi: 10.15171/jcvtr.2015.31
PMID: 26702342        PMCID: PMC4685279

Original Article

Ibuprofen - a Safe Analgesic During Cardiac Surgery Recovery? A Randomized Controlled Trial

Saddiq Mohammad Qazi 1 * , Eske Jesper Sindby 1, Martin Agge Nørgaard 1

Cited by CrossRef: 17


1- Singh R, Choudhury A, Chauhan S, Hote M. To Compare the Efficacy of Sub-Pecto-Interfascial Block with Erector Spinae Plane Block in Postoperative Pain Management in Patients Undergoing Cardiac Surgery. JCCC. 2024;8:101 [Crossref]
2- Tarasov E, Khinovker V, Svalov A, Koriachkin V, Fedorov D. Paravertebral block in pediatric cardiac surgery: a descriptive literature review. Regional Anesthesia and Acute Pain Management. 2024;18(4):312 [Crossref]
3- Milne B, Gilbey T, Kunst G. Perioperative Management of the Patient at High-Risk for Cardiac Surgery-Associated Acute Kidney Injury. Journal of Cardiothoracic and Vascular Anesthesia. 2022;36(12):4460 [Crossref]
4- Barr L, Boss M, Mazzeffi M, Taylor B, Salenger R. Postoperative Multimodal Analgesia in Cardiac Surgery. Critical Care Clinics. 2020;36(4):631 [Crossref]
5- Abou-Arab O, Yakoub-Agha M, Moussa M, Mauriat P, Provenchère S, Fellahi J, Besnier E. Nonsteroidal Antiinflammatory Drugs Used in Cardiac Surgery: A Survey of Practices and New Insights for Future Studies. Journal of Cardiothoracic and Vascular Anesthesia. 2024;38(1):349 [Crossref]
6- Cameron M, Tam K, Al Wahaibi K, Charghi R, Béïque F. Intraoperative Ketamine for Analgesia Post-Coronary Artery Bypass Surgery: A Randomized, Controlled, Double-Blind Clinical Trial. Journal of Cardiothoracic and Vascular Anesthesia. 2020;34(3):586 [Crossref]
7- Dağcan Şahin N, Gürol Arslan G. The effect of an open‐heart surgery patient care protocol on post‐sternotomy pain, anxiety and quality of care: A randomized controlled trial. Nursing in Critical Care. 2025;30(3) [Crossref]
8- Krakowski J, Hallman M, Smeltz A. Persistent Pain After Cardiac Surgery: Prevention and Management. Semin Cardiothorac Vasc Anesth. 2021;25(4):289 [Crossref]
9- Walker N, Jones V, Kratky L, Chen H, Runyan C. Hematoma Risks of Nonsteroidal Anti-inflammatory Drugs Used in Plastic Surgery Procedures. Ann Plast Surg. 2019;82(6S):S437 [Crossref]
10- Fjerbaek A, Westerdahl E, Andreasen J, Thomsen L, Brocki B. Change of position from a supine to a sitting position increases pulmonary function early after cardiac surgery. European Journal of Physiotherapy. 2020;22(6):313 [Crossref]
11- Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2. 2023;137(1):26 [Crossref]
12- McCARTHY C, SPRAY D, ZILHANI G, FLETCHER N. Perioperative care in cardiac surgery. Minerva Anestesiol. 2021;87(5) [Crossref]
13- Ma C, Tworek K, Kung J, Kilcommons S, Wheeler K, Parker A, Senaratne J, Macintyre E, Sligl W, Karvellas C, Zampieri F, Kutsogiannis D, Basmaji J, Lewis K, Chaudhuri D, Sharif S, Rewa O, Rochwerg B, Bagshaw S, Lau V. Systemic Nonsteroidal Anti-Inflammatories for Analgesia in Postoperative Critical Care Patients: A Systematic Review and Meta-Analysis of Randomized Control Trials. 2023;5(7):e0938 [Crossref]
14- Dost B, Turunc E, Aydin M, Kaya C, Aykut A, Demir Z, Narayanan M, De Cassai A. Pain Management in Minimally Invasive Cardiac Surgery: A Review of Current Clinical Evidence. Pain Ther. 2025;14(3):913 [Crossref]
15- Carini F, Lillo E, Vecchio G, Giannasi S, Castro D. Optimal Sedation in Ventilated Patients with Cardiovascular Surgery and/or Shock. Critical Care Clinics. 2025; [Crossref]
16- Huette P, Moussa M, Diouf M, Lefebvre T, Bayart G, Guilbart M, Viart C, Haye G, Bar S, Caus T, Soriot-Thomas S, Boddaert S, Alshatri H, Tarpin P, Fumery O, Beyls C, Dupont H, Mahjoub Y, Besnier E, Abou-Arab O. Effect of non-steroidal anti-inflammatory drugs on the management of postoperative pain after cardiac surgery: a multicenter, randomized, controlled, double-blind trial (KETOPAIN Study). Trials. 2024;25(1) [Crossref]
17- Engelman D, Ben Ali W, Williams J, Perrault L, Reddy V, Arora R, Roselli E, Khoynezhad A, Gerdisch M, Levy J, Lobdell K, Fletcher N, Kirsch M, Nelson G, Engelman R, Gregory A, Boyle E. Guidelines for Perioperative Care in Cardiac Surgery. JAMA Surg. 2019;154(8):755 [Crossref]
18- Schwartz J, Gan T. Management of postoperative nausea and vomiting in the context of an Enhanced Recovery after Surgery program. Best Practice & Research Clinical Anaesthesiology. 2020;34(4):687 [Crossref]
19- Bhatt H, Patel D, Rogando D, Abrams J, Shariat A. Multimodal Analgesia in Cardiothoracic Procedure: Opioid and Non-opioid Pharmacology for Pain Management: Part 1. 2025;28(3):228 [Crossref]
20- Ho A, Phelan R, Arellano R, Mizubuti G. Short-term use of nonsteroidal anti-inflammatory drugs immediately after cardiac surgery. Can J Anesth/J Can Anesth. 2025; [Crossref]
21- Miao T, Lee L, Sun T, Patapoff M, Wang E. Safety of nonselective nonsteroidal anti-inflammatory drugs in cardiac surgery: a historical cohort study. Can J Anesth/J Can Anesth. 2025; [Crossref]
22- Sherazee E, Chen S, Li D, Li D, Frank P, Kiaii B. Pain Management Strategies for Minimally Invasive Cardiothoracic Surgery. Innovations�(Phila). 2022;17(3):167 [Crossref]
23- Cameron M, Long J, Kardash K, Yang S. Superficial parasternal intercostal plane blocks in cardiac surgery: a systematic review and meta-analysis. Can J Anesth/J Can Anesth. 2024;71(6):883 [Crossref]
24- Sousa-Uva* M, Head S, Milojevic M, Collet J, Landoni G, Castella M, Dunning J, Gudbjartsson T, Linker N, Sandoval E, Thielmann M, Jeppsson A, Landmesser* U. 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery. 2018;53(1):5 [Crossref]