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J Cardiovasc Thorac Res. 2019;11(1): 61-67. doi: 10.15171/jcvtr.2019.10
PMID: 31024674        PMCID: PMC6477110

Original Article

Combination effect of voluntary exercise and garlic (Allium sativum) on oxidative stress, cholesterol level and histopathology of heart tissue in type 1 diabetic rats

Rafighe Ghyasi 1, Gisou Mohaddes 2, Roya Naderi 3,4 * ORCID

Cited by CrossRef: 15


1- Atale N, Yadav D, Rani V, Jin J. Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols. Front Nutr. 2020;7 [Crossref]
2- Akgun-Unal N, Ozyildirim S, Unal O, Gulbahce-Mutlu E, Mogulkoc R, Baltaci A. The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts. Experimental Gerontology. 2023;172:112043 [Crossref]
3- Jiang J, Ni L, Zhang X, Gokulnath P, Vulugundam G, Li G, Wang H, Xiao J. Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health. Advanced Biology. 2023;7(4) [Crossref]
4- Heydari H, Ghiasi R, Hamidian G, Ghaderpour S, Keyhanmanesh R. Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis. 2021;42(3):253 [Crossref]
5- Eltobshy S, Messiha R, Metias E, Sarhan M, El-Gamal R, El-Shaieb A, Ghalwash M. Effect of SGLT2 Inhibitor on Cardiomyopathy in a Rat Model of T2DM: Possible involvement of Cardiac Aquaporins. Tissue and Cell. 2023;85:102200 [Crossref]
6- Farzanegi P, Abbaszadeh H, Farokhi F, Rahmati-Ahmadabad S, Hosseini S, Abdi A, Mazandarani M, Rezaei I, Shokrie M, Vizvari E, Alinejad H, Azarbayjani M.

Attenuated Renal and Hepatic Cells Apoptosis Following Swimming Exercise Supplemented with Garlic Extract in Old Rats

. CIA. 2020;Volume 15:1409 [Crossref]
7- Ghiasi R, Alihemmati A, Naderi R. The impacts of garlic and voluntary training alone or together on myocardial miR-126 and miR-210 gene expressions and angiogenesis in healthy rats. J Cardiovasc Thorac Res. 2020;12(3):195 [Crossref]
8- Imaga N, Iheagwam F, Asibe C, Sogunle T, Chinedu S. Antidiabetic modulatory effects of Vernonia amygdalina and Allium sativum combined extract in streptozotocin-induced diabetic rats. Vegetos. 2022;36(2):615 [Crossref]
9- Lee H, Khan R, Vally M, Orchard A. A scoping review on natural cholesterol lowering supplements sold in South African pharmacies. Health SA Gesondheid. 2024;29 [Crossref]
10- Naderi R, Pourheydar B, Ghiasi R, Shafiei F. Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence. 2020;41(3) [Crossref]
11- Cascajosa-Lira A, Pichardo S, Baños A, Guillamón E, Molina-Hernández V, Moyano R, Jos Á, Cameán A. Acute and subchronic 90-days toxicity assessment of propyl-propane-thiosulfinate (PTS) in rats. Food and Chemical Toxicology. 2022;161:112827 [Crossref]
12- Qin X, Su T, Kojima S. Prevention of arachidonic acid‑induced liver injury by controlling oxidative stress‑mediated transglutaminase activation with garlic extracts. Exp Ther Med. 2019; [Crossref]
13- Amini M, Saboory E, Pourheydar B, Bagheri M, Naderi R. Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: Role of 5-HT3 receptor antagonist. International Immunopharmacology. 2020;79:106158 [Crossref]
14- Sánchez-Sánchez M, Zepeda-Morales A, Carrera-Quintanar L, Viveros-Paredes J, Franco-Arroyo N, Godínez-Rubí M, Ortuño-Sahagun D, López-Roa R. Alliin, An Allium sativum Nutraceutical, Reduces Metaflammation Markers in DIO Mice. Nutrients. 2020;12(3):624 [Crossref]
15- Davaran M, Abdi A, Mehrabani J, Abbassi Daloii A. Response of Cardiac Tissue Oxidative Stress After Aerobic Exercise and Capsaicin Administrations in Rats Fed High-Fat Diet. Zahedan J Res Med Sci. 2021;24(1) [Crossref]
16- Skoczylas J, Jędrszczyk E, Dziadek K, Dacewicz E, Kopeć A. Basic Chemical Composition, Antioxidant Activity and Selected Polyphenolic Compounds Profile in Garlic Leaves and Bulbs Collected at Various Stages of Development. Molecules. 2023;28(18):6653 [Crossref]
17- Ribeiro M, Alvarenga L, Cardozo L, Chermut T, Sequeira J, de Souza Gouveia Moreira L, Teixeira K, Shiels P, Stenvinkel P, Mafra D. From the distinctive smell to therapeutic effects: Garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease. Clinical Nutrition. 2021;40(7):4807 [Crossref]