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J Cardiovasc Thorac Res. 2022;14(2): 128-137. doi: 10.34172/jcvtr.2022.23
PMID: 35935389        PMCID: PMC9339728

Original Article

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

Atefeh Naghdi 1 ORCID, Mohammad Taghi Goodarzi 1,2, Jamshid Karimi 1, Mohammad Hashemnia 3, Iraj Khodadadi 1 * ORCID

Cited by CrossRef: 3

1- Ni D, Xu J, Liu K, Wu N, You B, Yang B, Dai Y. Curcumin ameliorates pyroptosis in diabetic seminal vesicles by upregulating TRPV6. Andrology. 2025;13(3):624 [Crossref]
2- Abdel-Halim N, Eid E, Yehya Y, Taha M, Mosa A, Ammar O, Nasr A, Hussin E, Hussein A. Effect of New Antidiabetics on Steatosis in Nerve Tissues and Nerve Conduction Velocity: Possible Role of Nerve Growth Factor (NGF)/Synaptophysin and Nrf2/HO-1 Pathways. 2024; [Crossref]
3- Kumar R, Pandey A, Vibhuti A, Ali M, Chang C, Pandey R. Unlocking Mysteries: Exploring the Dynamic Interplay among Sleep, the Immune System, and Curcumin in Contemporary Research. Sleep Sci. 2025; [Crossref]
4- Malaekeh-Nikouei A, Shokri-Naei S, Karbasforoushan S, Bahari H, Baradaran Rahimi V, Heidari R, Askari V. Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomedicine & Pharmacotherapy. 2023;165:115263 [Crossref]
5- Abdel-Zaher A, Bakr M, Gad Y, Abdelhafez A. Novel mechanistic insights of the potential role of gasotransmitters and autophagy in the protective effect of metformin against hepatic ischemia/reperfusion injury in rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2025; [Crossref]
6- Campagna R, Cecati M, Vignini A. The Multifaceted Role of the Polyphenol Curcumin: A Focus on Type 2 Diabetes Mellitus. CDR. 2025;21(8) [Crossref]
7- Ermiş M, Çiftci G. Role of curcumin on beta-amyloid protein, tau protein, and biochemical and oxidative changes in streptozotocin-induced diabetic rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(12):9833 [Crossref]
8- Dhiman P, Malik N. Curcumin Derivatives Linked to a Reduction of Oxidative Stress in Mental Dysfunctions and Inflammatory Disorders. CMC. 2024;31(41):6826 [Crossref]
9- Liu X, Qiu Q, Yu T, Wang L, Shi L, Wang B, Sang Y, Geng H, Zhang Y, Zhang X, Li L, Li Q, Liang J, Xu W. Effect of metformin on Wnt5a in individuals new-onset type 2 diabetes with different body mass indexes: The evidences from the real word research. J Diabetes Metab Disord. 2023;22(2):1561 [Crossref]
10- Li Z, Wang B, Bai D, Zhang L. Brazil nut (Bertholletia excelsa) and metformin abrogate cardiac complication in fructose/STZ-induced type 2 diabetic rats by attenuating oxidative stress and modulating the MAPK-mTOR/NFkB/IL-10 signaling pathways. Food & Nutrition Research. 2024;68 [Crossref]
11- Yagci T, Genc S, Dundar R, Altiner H, Taghizadehghalehjoughi A. A Combination of Anatolian Propolis and Curcumin Protects Fibroblasts Against Beclomethasone (Nazal Steroid)-Induced Oxidative Stress by Modulating IL-25, MMP-2, VEGF, and FGF-2 Expressions. Pharmaceuticals. 2025;18(3):326 [Crossref]
12- Pourmousavi L, Hashemkandi Asadi R, Zehsaz F, Jadidi R, Al-Awaida W. Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats. PLoS ONE. 2023;18(12):e0281692 [Crossref]
13- Sun S, Hou X, Li K, Huang C, Rong Y, Bi J, Li X, Wu D. Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections. JFB. 2024;15(12):388 [Crossref]
14- Wilar G, Suhandi C, Fukunaga K, Shigeno M, Kawahata I, Abdulah R, Sasaki T. Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research. 2025;213:107641 [Crossref]
15- Jin D, Jin S, Sheng G, Cui Z, Gao P, Li G. Effects of Curcumin on Postmenopausal Women's Health: A Systematic Review and Meta‐Analysis. Phytotherapy Research. 2025;39(5):2202 [Crossref]